Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor
neurons, which results in weakness and atrophy of voluntary skeletal muscles. Treatments …

The first reports of disorders that in terms of cognitive and behavioral symptoms resemble
frontotemporal dementia (FTD) and in terms of motor symptoms resemble amyotrophic …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with a substantial
heritable component. In pedigrees affected by its familial form, incomplete penetrance is …

Amyotrophic lateral sclerosis (ALS) is increasingly recognized to be a multisystem disorder
which includes both clinical and neuropathological features of a frontotemporal lobar …

Glia and microglia in particular elaborate pro‐inflammatory molecules that play key roles in
central nervous system (CNS) disorders from neuropathic pain and epilepsy to …

Background Mutations in SOD1, ANG, VAPB, TARDBP and FUS genes have been identified
in amyotrophic lateral sclerosis (ALS). Methods The relative contributions of the different …

One of the more important recent advances in neuroscience research is the understanding
that there is extensive communication between the immune system and the central nervous …

The past few years have seen the identification of dozens of genes with causal roles in
motor neuron diseases (MNDs), particularly for amyotrophic lateral sclerosis and hereditary …

Angiogenin induces angiogenesis by activating vessel endothelial and smooth muscle cells
and triggering a number of biological processes, including cell migration, invasion …

Objective: To assess the frequency and clinical characteristics of patients with mutations of
major amyotrophic lateral sclerosis (ALS) genes in a prospectively ascertained, population …