2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association

SS Martin, AW Aday, ZI Almarzooq, CAM Anderson… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

Research Opportunities in the Treatment of Mitral Valve Prolapse: JACC Expert Panel

FN Delling, PA Noseworthy, DH Adams… - Journal of the American …, 2022 - jacc.org
In light of the adverse prognosis related to severe mitral regurgitation, heart failure, or
sudden cardiac death in a subset of patients with mitral valve prolapse (MVP), identifying …

Genetics and pathophysiology of mitral valve prolapse

C Delwarde, R Capoulade, J Mérot… - Frontiers in …, 2023 - frontiersin.org
Mitral valve prolapse (MVP) is a common condition affecting 2–3% of the general
population, and the most complex form of valve pathology, with a complication rate up to 10 …

Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model

C Delwarde, C Toquet, P Aumond… - Cardiovascular …, 2023 - academic.oup.com
Aims Degenerative mitral valve dystrophy (MVD) leading to mitral valve prolapse is the most
frequent form of MV disease, and there is currently no pharmacological treatment available …

The future of valvular heart disease assessment and therapy

PP Sengupta, J Kluin, SP Lee, JK Oh, AIPM Smits - The Lancet, 2024 - thelancet.com
Valvular heart disease (VHD) is becoming more prevalent in an ageing population, leading
to challenges in diagnosis and management. This two-part Series offers a comprehensive …

[HTML][HTML] Genetic background of mitral valve prolapse

NA Guicciardi, M De Bonis, C Di Resta… - Reviews in …, 2022 - imrpress.com
Mitral valve prolapse (MVP) has a prevalence of 2–3% among the population. It involves a
heterogeneous group of patients with different expressions and according to the phenotype …

Biology of mitral valve prolapse: from general mechanisms to advanced molecular patterns—a narrative review

D Ronco, G Buttiglione, A Garatti… - Frontiers in …, 2023 - frontiersin.org
Mitral valve prolapse (MVP) represents the most frequent cause of primary mitral
regurgitation. For several years, biological mechanisms underlying this condition attracted …

FOXC1 and FOXC2 Ablation Causes Abnormal Valvular Endothelial Cell Junctions and Lymphatic Vessel Formation in Myxomatous Mitral Valve Degeneration

C Tan, ZD Ge, S Kurup, Y Dyakiv, T Liu… - … , and vascular biology, 2024 - ahajournals.org
BACKGROUND: Mitral valve (MV) disease including myxomatous degeneration is the most
common form of valvular heart disease with an age-dependent frequency. Genetic evidence …

[HTML][HTML] FOXC1 and FOXC2 maintain mitral valve endothelial cell junctions, extracellular matrix, and lymphatic vessels to prevent myxomatous degeneration

C Tan, S Kurup, Y Dyakiv, T Kume - bioRxiv, 2023 - ncbi.nlm.nih.gov
Background: Mitral valve (MV) disease including myxomatous degeneration is the most
common form of valvular heart disease with an age-dependent frequency. Genetic evidence …

[HTML][HTML] Valvulopathies and Genetics: Where are We?

M Coll, A Fernández-Falgueras, A Iglesias… - Reviews in …, 2024 - imrpress.com
Valvulopathies are among the most common cardiovascular diseases, significantly
increasing morbidity and mortality. While many valvular heart diseases are acquired later in …