Selecting the optimal immunotherapy regimen in driver-negative metastatic NSCLC

MJ Grant, RS Herbst, SB Goldberg - Nature reviews Clinical oncology, 2021 - nature.com
The treatment landscape of driver-negative non-small-cell lung cancer (NSCLC) is rapidly
evolving. Immune-checkpoint inhibitors, specifically those targeting PD-1 or PD-L1, have …

[HTML][HTML] Breast cancer with brain metastasis: molecular insights and clinical management

M Ivanova, FM Porta, F Giugliano, C Frascarelli… - Genes, 2023 - mdpi.com
Breast cancer is the most frequently diagnosed malignancy worldwide and the leading
cause of cancer-related death among women. Brain metastases are a primary contributor to …

[HTML][HTML] PD-L1 expression in Chinese patients with advanced non-small cell lung cancer (NSCLC): a multi-center retrospective observational study

X Yang, L Jiang, Y Jin, P Li, Y Hou, J Yun, C Wu… - Journal of …, 2021 - ncbi.nlm.nih.gov
Objective: This study aimed to investigate the prevalence of tumor programmed death-ligand
1 (PD-L1) expression in Chinese patients with advanced Non-Small Cell Lung Cancer …

Anti-PD-(L) 1 immunotherapy for brain metastases in non-small cell lung cancer: Mechanisms, advances, and challenges

S Zhou, J Xie, Z Huang, L Deng, L Wu, J Yu, X Meng - Cancer Letters, 2021 - Elsevier
The brain is one of the most common metastatic sites in non-small cell lung cancer
(NSCLC), which is associated with an extremely poor prognosis. Despite the availability of …

[HTML][HTML] Navigate towards the immunotherapy era: value of immune checkpoint inhibitors in non-small cell lung cancer patients with brain metastases

G Yang, L Xing, X Sun - Frontiers in Immunology, 2022 - frontiersin.org
Brain metastases (BMs) in non-small-cell lung cancer (NSCLC) patients are associated with
significant morbidity and poor prognosis. Immune checkpoint inhibitors (ICIs) have resulted …

Systemic therapy for lung cancer brain metastases

A Pellerino, F Bruno, R Rudà, R Soffietti - Current Treatment Options in …, 2021 - Springer
Opinion statement Systemic therapy for brain metastases (BM) is quickly moving from
conventional cytotoxic chemotherapy toward targeted therapies, that allow a disruption of …

Effectiveness of Immune Checkpoint Inhibition vs Chemotherapy in Combination With Radiation Therapy Among Patients With Non–Small Cell Lung Cancer and …

D Wasilewski, J Radke, R Xu, M Raspe… - JAMA Network …, 2022 - jamanetwork.com
Importance Patients with brain metastases from non–small cell lung cancer (NSCLC) have
regularly been excluded from prospective clinical trials that include therapy with immune …

[HTML][HTML] Brain metastases and lung cancer: molecular biology, natural history, prediction of response and efficacy of immunotherapy

M Sereno, I Hernandez de Córdoba… - Frontiers in …, 2024 - frontiersin.org
Brain metastases stemming from lung cancer represent a common and challenging
complication that significantly impacts patients' overall health. The migration of these …

[HTML][HTML] Progress of immune checkpoint inhibitors therapy for non-small cell lung cancer with brain metastases

X Yan, F Qu, Y Zhou - Lung Cancer, 2023 - Elsevier
About 40% of patients with non-small cell lung cancer (NSCLC) develop brain metastases
(BMs) throughout the disease, and the occurrence of BMs is considered to have a fairly high …

[HTML][HTML] The immune microenvironment of chordomas: An immunohistochemical analysis

M Dridi, L Krebs-Drouot, D Meyronet, JM Dumollard… - Cancers, 2021 - mdpi.com
Simple Summary Chordoma patients may be amenable to immunotherapy; however, the
immune microenvironment of chordomas needs further investigation. We performed the …