Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …

Glioblastoma multiforme (GBM) is the most aggressive type of primary brain tumor and is
associated with a poor clinical prognosis. Despite the progress in the understanding of the …

Hypoxia exerts a profound impact on diverse aspects of cancer biology. Increasing evidence
has revealed novel functions of hypoxia in cancer cell epigenomics, epitranscriptomics …

Blood-borne metastasis to the brain is a major complication of breast cancer, but cellular
pathways that enable cancer cells to selectively grow in the brain microenvironment are …

Functional biomaterials that couple angiogenesis and osteogenesis processes are vital for
bone tissue engineering and bone remodeling. Herein we developed an injectable …

Colorectal cancer (CRC) has a global burden of disease. Our current understanding of CRC
has progressed from initial discoveries which focused on the stepwise accumulation of key …

Angiogenesis is a pathological signature of intervertebral disc degeneration (IDD).
Accumulating evidence has shown that notochordal cells (NCs) play an essential role in …

Crosslinking of polymeric network using nanoparticles by physical or chemical method to
obtain hydrogel is an emerging approach. Herein, we synthesized Polydopamine (PDA) …

Background The triple negative breast cancer (TNBC) paradox marks a major challenge in
the treatment-decision making process. TNBC patients generally respond better to …

Histone deacetylase inhibitors (HDACis) are a potent class of tumor-suppressive agents
traditionally believed to exert their effects through loosening tightly-wound chromatin …