Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology

SJ Forrester, GW Booz, CD Sigmund… - Physiological …, 2018 - journals.physiology.org
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation

Z Bekassy, I Lopatko Fagerström, M Bader… - Nature Reviews …, 2022 - nature.com
During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …

COVID-19 and hypertension: the what, the why, and the how

SA Muhamad, A Ugusman, J Kumar, D Skiba… - Frontiers in …, 2021 - frontiersin.org
It has been a year since the coronavirus disease 2019 (COVID-19) was declared pandemic
and wreak havoc worldwide. Despite meticulous research has been done in this period …

Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?

MC Chappell - American Journal of Physiology-Heart and …, 2016 - journals.physiology.org
The renin-angiotensin system (RAS) constitutes a key hormonal system in the physiological
regulation of blood pressure through peripheral and central mechanisms. Indeed …

Molecular mechanisms of autophagy in the cardiovascular system

D Gatica, M Chiong, S Lavandero… - Circulation research, 2015 - Am Heart Assoc
Autophagy is a catabolic recycling pathway triggered by various intra-or extracellular stimuli
that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents …

ACE inhibition, ACE2 and angiotensin-(1⿿ 7) axis in kidney and cardiac inflammation and fibrosis

ACS e Silva, MM Teixeira - Pharmacological research, 2016 - Elsevier
Abstract The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …

[HTML][HTML] Many faces of renin-angiotensin system-focus on eye

M Holappa, H Vapaatalo… - The open ophthalmology …, 2017 - ncbi.nlm.nih.gov
The renin-angiotensin system (RAS), that is known for its role in the regulation of blood
pressure as well as in fluid and electrolyte homeostasis, comprises dozens of angiotensin …

Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV

S Li, Z Tang, Z Li, X Liu - European Journal of Clinical Microbiology & …, 2020 - Springer
Since December 2019, the infection of the new coronavirus (COVID-19) caused an outbreak
of new coronavirus pneumonia in Wuhan, China, and caused great public concern. Both …

ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension

E Mendoza-Torres, A Oyarzún… - Therapeutic …, 2015 - journals.sagepub.com
The renin–angiotensin system (RAS) is a key component of cardiovascular physiology and
homeostasis due to its influence on the regulation of electrolyte balance, blood pressure …

Renin–angiotensin system: an important player in the pathogenesis of acute respiratory distress syndrome

J Hrenak, F Simko - International journal of molecular sciences, 2020 - mdpi.com
Acute respiratory distress syndrome (ARDS) is characterized by massive inflammation,
increased vascular permeability and pulmonary edema. Mortality due to ARDS remains very …