Microbiomes are ubiquitous and are found in the ocean, the soil, and in/on other living
organisms. Changes in the microbiome can impact the health of the environmental niche in …

Cytoscape is open-source software for integration, visualization and analysis of biological
networks. It can be extended through Cytoscape plugins, enabling a broad community of …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …

Computational analysis and interactive visualization of biological networks and protein
structures are common tasks for gaining insight into biological processes. This protocol …

Recent studies across multiple tumour types are starting to reveal a recurrent regulatory
architecture in which genomic alterations cluster upstream of functional master regulator …

The immune system is a highly complex and dynamic system. Historically, the most common
scientific and clinical practice has been to evaluate its individual components. This kind of …

To protect the genome, cells have evolved a diverse set of pathways designed to sense,
signal, and repair multiple types of DNA damage. To assess the degree of coordination and …

The detection of community structure is a widely accepted means of investigating the
principles governing biological systems. Recent efforts are exploring ways in which multiple …

Efficient repair of UV-induced DNA damage requires the precise coordination of nucleotide
excision repair (NER) with numerous other biological processes. To map this crosstalk, we …