The innate immune system recognizes microbial products using germline-encoded
receptors that initiate inflammatory responses to infection. The bacterial cell wall component …

Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …

Degradation of Gram-positive bacterial cell wall peptidoglycan in macrophage and dendritic
cell phagosomes leads to activation of the NLRP3 inflammasome, a cytosolic complex that …

Over the past several decades, much has been revealed about the nature of the host innate
immune response to microorganisms, with the identification of pattern recognition receptors …

Inflammasomes are multiprotein complexes that activate caspase-1, which leads to
maturation of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 and the …

The NLRP3 inflammasome has a major role in regulating innate immunity. Deregulated
inflammasome activity is associated with several inflammatory diseases, yet little is known …

The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein
complex that activates caspase 1, leading to the processing and secretion of the pro …

Inhalation of silica crystals causes inflammation in the alveolar space. Prolonged exposure
to silica can lead to the development of silicosis, an irreversible, fibrotic pulmonary disease …

The inflammasome is a multiprotein complex that mediates the activation of caspase-1,
which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 …