Viral infections and male infertility: a comprehensive review of the role of oxidative stress

RE Akhigbe, S Dutta, MA Hamed, AF Ajayi… - … in Reproductive Health, 2022 - frontiersin.org
Viral infections have been a part of human existence to date, though viruses have posed a
huge threat with various outbreaks lately. These threats are associated with reproductive …

Irisin, energy homeostasis and male reproduction

P Sengupta, S Dutta, IR Karkada, RE Akhigbe… - Frontiers in …, 2021 - frontiersin.org
Irisin is a novel skeletal muscle-and adipose tissue-secreted peptide. It is conventionally
regarded as an adipomyokine and is a cleaved fragment of Fibronectin type III domain …

[HTML][HTML] Glutamine restores testicular glutathione-dependent antioxidant defense and upregulates NO/cGMP signaling in sleep deprivation-induced reproductive …

MA Hamed, TM Akhigbe, RE Akhigbe… - Biomedicine & …, 2022 - Elsevier
Oxidative stress has been linked with sleep deprivation (SD)-induced pathological
conditions and reproductive dysfunction. On the other hand, glutamine has been established …

[HTML][HTML] Suppression of uric acid generation and blockade of glutathione dysregulation by L-arginine ameliorates dichlorvos-induced oxidative hepatorenal damage in …

WA Saka, RE Akhigbe, AO Abidoye, OS Dare… - Biomedicine & …, 2021 - Elsevier
Dichlorvos is a known risk factor for organ toxicity. The liver and kidney are essential
metabolic tissues but it is unclear whether or not there is associated redox dyshomeostasis …

Zinc normalizes hepatic lipid handling via modulation of ADA/XO/UA pathway and caspase 3 signaling in highly active antiretroviral therapy-treated Wistar rats

MA Hamed, RE Akhigbe, AO Aremu… - Chemico-Biological …, 2022 - Elsevier
Background Although highly active antiretroviral therapy (HAART) is effective in the
management of HIV, it has been reported to induce hepatic injury and non-alcoholic fatty …

Atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative damage and apoptosis induced by ovarian ischaemia/reperfusion …

OA Afolabi, MA Hamed, DC Anyogu, DH Adeyemi… - Redox …, 2022 - Taylor & Francis
Background Oxidative damage is critical in the pathogenesis of ovarian
ischaemia/reperfusion (I/R) injury, and statins have been reported to exert antioxidant …

Restoration of Hepatic and Intestinal Integrity by Phyllanthus amarus Is Dependent on Bax/Caspase 3 Modulation in Intestinal Ischemia-/Reperfusion-Induced Injury

AO Afolabi, TM Akhigbe, AF Odetayo, DC Anyogu… - Molecules, 2022 - mdpi.com
Ethnopharmacological relevance: Oxidative stress is a key player in intestinal
ischemia/reperfusion (I/R) injury (IIRI) with a tendency to trigger systemic inflammatory …

Methanolic Moringa oleifera leaf extract protects against epithelial barrier damage and enteric bacterial translocation in intestinal I/R: Possible role of caspase 3

OA Afolabi, TM Akhigbe, RE Akhigbe… - Frontiers in …, 2022 - frontiersin.org
Background: Activation of caspase 3 has been implicated in the pathogenesis of I/R injury in
various organs, but there is a paucity of data on its role in IIRI. Also, no reports were found …

Sodium acetate ameliorates doxorubicin-induced cardiac injury via upregulation of Nrf2/HO-1 signaling and downregulation of NFkB-mediated apoptotic signaling in …

DH Adeyemi, OO Obembe, MA Hamed… - Naunyn-Schmiedeberg's …, 2024 - Springer
Despite the effectiveness of doxorubicin (DOX) in the management of a wide range of
cancers, a major challenge is its cardio-toxic effect. Oxidative stress, inflammation, and …

HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content

RE Akhigbe, MA Hamed, AO Aremu - Reproductive Toxicology, 2021 - Elsevier
Highly active anti-retroviral therapy (HAART) is an effective anti-retroviral cocktail. Similarly,
anti-Koch is highly potent against Mycobacterium tuberculosis. However, these drugs have …