Intracellular organelles are subsystems within a cell, whose activity and chemical
composition reflect the metabolic state of live cells. Alterations in cellular homeostasis …

Goblet cells and the mucus they secrete serve as an important barrier, preventing pathogens
from invading the mucosa to cause intestinal inflammation. The perspective regarding goblet …

In this review we discuss mucus, the viscoelastic secretion from goblet or mucous producing
cells that lines the epithelial surfaces of all organs exposed to the external world. Mucus is a …

The airway epithelium is now considered to be central to the orchestration of pulmonary
inflammatory and immune responses, and is also key to tissue remodelling. It acts as the first …

Goblet cells and their main secretory product, mucus, have long been poorly appreciated;
however, recent discoveries have changed this and placed these cells at the center stage of …

Mucus forms a protective coating on wet epithelial surfaces throughout the body that houses
the microbiota and plays a key role in host defense. Mucins, the primary structural …

Recent evidence suggests that the airway mucus gel layer may be impermeable to the viral
and synthetic gene vectors used in past inhaled gene therapy clinical trials for diseases like …

Mucus is an integral part of the respiratory physiology. It protects the respiratory tract by
acting as a physical barrier against inhaled particles and microbes. Excessive inflammation …

Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. Only
a fraction of NSCLC harbor actionable driver mutations and there is an urgent need for …

In the lung, the airway epithelium produces secreted and tethered mucin biopolymers to
form a mucus hydrogel layer and a surface-attached polymer brush layer. These layers work …