Genetic variation and adaptation in Africa: implications for human evolution and disease
Because modern humans originated in Africa and have adapted to diverse environments,
African populations have high levels of genetic and phenotypic diversity. Thus, genomic …
African populations have high levels of genetic and phenotypic diversity. Thus, genomic …
New approaches to disease mapping in admixed populations
MF Seldin, B Pasaniuc, AL Price - Nature Reviews Genetics, 2011 - nature.com
Admixed populations such as African Americans and Hispanic Americans are often
medically underserved and bear a disproportionately high burden of disease. Owing to the …
medically underserved and bear a disproportionately high burden of disease. Owing to the …
RFMix: a discriminative modeling approach for rapid and robust local-ancestry inference
Local-ancestry inference is an important step in the genetic analysis of fully sequenced
human genomes. Current methods can only detect continental-level ancestry (ie, European …
human genomes. Current methods can only detect continental-level ancestry (ie, European …
Genomic variation in seven Khoe-San groups reveals adaptation and complex African history
The history of click-speaking Khoe-San, and African populations in general, remains poorly
understood. We genotyped∼ 2.3 million single-nucleotide polymorphisms in 220 southern …
understood. We genotyped∼ 2.3 million single-nucleotide polymorphisms in 220 southern …
High prevalence of diabetes mellitus and metabolic syndrome in a South African coloured population: Baseline data of a study in Bellville, Cape Town
RT Erasmus, DJ Soita, MS Hassan… - South African Medical …, 2012 - ajol.info
Objective. The coloured population has the second-highest prevalence of diabetes in South
Africa. However, the data were based on a study conducted almost 20 years ago in a peri …
Africa. However, the data were based on a study conducted almost 20 years ago in a peri …
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population
The worldwide burden of tuberculosis (TB) remains an enormous problem, and is
particularly severe in the admixed South African Coloured (SAC) population residing in the …
particularly severe in the admixed South African Coloured (SAC) population residing in the …
[HTML][HTML] PCAdmix: principal components-based assignment of ancestry along each chromosome in individuals with admixed ancestry from two or more populations
Identifying ancestry along each chromosome in admixed individuals provides a wealth of
information for understanding the population genetic history of admixture events and is …
information for understanding the population genetic history of admixture events and is …
Genetic substructure and complex demographic history of South African Bantu speakers
Abstract South Eastern Bantu-speaking (SEB) groups constitute more than 80% of the
population in South Africa. Despite clear linguistic and geographic diversity, the genetic …
population in South Africa. Despite clear linguistic and geographic diversity, the genetic …
Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans
Abstract The Southern African Human Genome Programme is a national initiative that
aspires to unlock the unique genetic character of southern African populations for a better …
aspires to unlock the unique genetic character of southern African populations for a better …
Quality of life in patients on chronic dialysis in South Africa: a comparative mixed methods study
Background The increasing prevalence of treated end-stage renal disease and low
transplant rates in Africa leads to longer durations on dialysis. Dialysis should not only be …
transplant rates in Africa leads to longer durations on dialysis. Dialysis should not only be …