The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is regarded as a
potential anticancer agent. However, considerable numbers of cancer cells, especially some …

Programmed cell death via apoptosis is characteristically disturbed in human cancers. This
facilitates not only tumor formation and progression, but also treatment resistance. Since …

Apoptosis and autophagy are both tightly regulated biological processes that play a central
role in tissue homeostasis, development, and disease. The anti-apoptotic protein, Bcl-2 …

Cell death plays an essential role in the development of organs, homeostasis, and cancer.
Apoptosis and programmed necrosis are two major types of cell death, characterized by …

Anti‐tumour therapies based on the use pro‐apoptotic receptor agonists, including TNF‐
related apoptosis‐inducing ligand (TRAIL) or monoclonal antibodies targeting TRAIL‐R1 or …

Over the past two decades, the role of apoptosis in the cytotoxicity of anticancer drugs has
become clear. Apoptosis may occur via a death receptor‐dependent (extrinsic) or …

Formation of the pro-apoptotic death-inducing signaling complex (DISC) can be initiated in
cancer cells via binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) …

Background Gastric cancer is one of the most common cancers in the world. The
“economically developed countries” life style, including diet, constitutes a risk factor favoring …

Killing of tumor cells by anticancer therapies commonly used in the treatment of cancer, eg
chemotherapy, γ-irradiation, immunotherapy or suicide gene therapy, is predominantly …

Cellular-FLICE inhibitory protein (c-FLIP) is a key anti-apoptotic regulator that inhibits cell
death mediated by the death receptors Fas, DR4, DR5, and TNF-R1. Three splice variants of …