The homochirality of biomolecules in nature, such as DNA, RNA, peptides and proteins, has
played a critical role in establishing and sustaining life on Earth. This chiral bias has also …

Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

The design of bioactive supramolecular chirality is always hampered by the lack of feasible
schemes to assigned specific biological activities. Herein, we developed a “mirror-image …

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

The MDM2 and MDMX (also known as HDMX and MDM4) proteins are deregulated in many
human cancers and exert their oncogenic activity predominantly by inhibiting the p53 tumour …

The tumour suppressor p53 is the most frequently mutated gene in human cancer, with more
than half of all human tumours carrying mutations in this particular gene. Intense efforts to …

Unnatural helical peptidic foldamers have attracted considerable attention owing to their
unique folding behaviours, diverse artificial protein binding mechanisms, and promising …

Blockade of the protein–protein interaction between the transmembrane protein
programmed cell death protein 1 (PD‐1) and its ligand PD‐L1 has emerged as a promising …

Widespread adoption of mirror-image biological systems presents difficulties in accessing
the requisite D-protein substrates. In particular, mirror-image phage display has the potential …

The contradiction between the rising demands of optical chirality sensing and the failure in
chiral detection of cryptochiral compounds encourages researchers to find new methods for …