Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Defects in DNA repair pathways are a major cause of DNA damage accumulation leading to
genomic instability and neurodegeneration. Efficient DNA damage repair is critical to …

Wnt/β-catenin (WβC) signaling pathway is an important signaling pathway for the
maintenance of cellular homeostasis from the embryonic developmental stages to …

Skeletal muscle is essential for locomotion, metabolism, and protein homeostasis in the
body. Mitochondria have been considered as a key target to regulate metabolic switch …

Spinal muscular atrophy (SMA) is a genetic disorder characterized by the loss of spinal
motor neurons leading to muscle weakness and respiratory failure. Mitochondrial …

Background. Mitochondrial biogenesis‐related studies have increased rapidly within the last
20 years, whereas there has been no bibliometric analysis on this topic to reveal relevant …

Whether neurodevelopmental defects underlie postnatal neuronal death in
neurodegeneration is an intriguing hypothesis only recently explored. Here, we focus on …

Neuro-muscular disorders include a variety of diseases induced by genetic mutations
resulting in muscle weakness and waste, swallowing and breathing difficulties. However …

Background Spinal muscular atrophy (SMA) is an autosomal recessive childhood-onset
neuromuscular disease with a carrier frequency of~ 1: 50. Mitochondrial abnormalities are …

The most prevalent rare genetic disease affecting young individuals is spinal muscular
atrophy (SMA), which is caused by a loss-of-function mutation in the telomeric gene survival …