Natural products against key Mycobacterium tuberculosis enzymatic targets: Emerging opportunities for drug discovery

G Cazzaniga, M Mori, LR Chiarelli, A Gelain… - European journal of …, 2021 - Elsevier
For centuries, natural products (NPs) have served as powerful therapeutics against a variety
of human ailments. Nowadays, they still represent invaluable resources for the treatment of …

Promiscuous targets for antitubercular drug discovery: The paradigm of DprE1 and MmpL3

G Degiacomi, JM Belardinelli, MR Pasca, E De Rossi… - Applied Sciences, 2020 - mdpi.com
The development and spread of Mycobacterium tuberculosis multi-drug resistant strains still
represent a great global health threat, leading to an urgent need for novel anti-tuberculosis …

Role of post‐translational modifications in the acquisition of drug resistance in Mycobacterium tuberculosis

G Arora, A Bothra, G Prosser, K Arora… - The FEBS …, 2021 - Wiley Online Library
Tuberculosis (TB) is one of the primary causes of deaths due to infectious diseases. The
current TB regimen is long and complex, failing of which leads to relapse and/or the …

Antivirulence compounds: a future direction to overcome antibiotic resistance?

S Buroni, LR Chiarelli - Future Microbiology, 2020 - Taylor & Francis
The evolution and spread of antimicrobial resistance (AMR) is recognized as a major threat
to global health and to healthcare systems, being the cause for almost 700,000 deaths …

Importance of protein Ser/Thr/Tyr phosphorylation for bacterial pathogenesis

J Bonne Køhler, C Jers, M Senissar, L Shi… - FEBS …, 2020 - Wiley Online Library
Protein phosphorylation regulates a large variety of biological processes in all living cells. In
pathogenic bacteria, the study of serine, threonine, and tyrosine (Ser/Thr/Tyr) …

Synthesis, characterization, and biological evaluation of new derivatives targeting MbtI as antitubercular agents

M Mori, G Stelitano, LR Chiarelli, G Cazzaniga… - Pharmaceuticals, 2021 - mdpi.com
Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most
dangerous infectious diseases worldwide. Because several pathogenic strains of …

From infection niche to therapeutic target: the intracellular lifestyle of Mycobacterium tuberculosis

LI Rankine-Wilson, T Shapira, C Sao Emani… - …, 2021 - microbiologyresearch.org
Mycobacterium tuberculosis (Mtb) is an obligate human pathogen killing millions of people
annually. Treatment for tuberculosis is lengthy and complicated, involving multiple drugs …

Mycobacterium tuberculosis and Pulmonary Rehabilitation: From Novel Pharmacotherapeutic Approaches to Management of Post-Tuberculosis Sequelae

AD Meca, L Mititelu-Tarțău, M Bogdan… - Journal of personalized …, 2022 - mdpi.com
Tuberculosis (TB) is still a worldwide public health burden, as more than 1.3 million deaths
are expected to be reported in 2021. Even though almost 20 million patients have completed …

Evaluation of small molecule kinase inhibitors as novel antimicrobial and antibiofilm agents

A King, MS Blackledge - Chemical biology & drug design, 2021 - Wiley Online Library
Antibiotic resistance is a global and pressing concern. Our current therapeutic arsenal is
increasingly limited as bacteria are developing resistance at a rate that far outpaces our …

Predictive Binding Affinity of Plant-Derived Natural Products Towards the Protein Kinase G Enzyme of Mycobacterium tuberculosis (MtPknG)

RM Qasaymeh, D Rotondo, CB Oosthuizen, N Lall… - Plants, 2019 - mdpi.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a growing public health
concern worldwide, especially with the emerging challenge of drug resistance to the current …