Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of
outbreaks accompanied by unexpectedly severe clinical complications brought this virus …

The ongoing Zika virus (ZIKV) epidemic and unexpected clinical outcomes, including
Guillain-Barré syndrome and birth defects, has brought an urgent need for animal models …

Sand flies (Diptera: Phlebotominae) are proven vectors of various pathogens of medical and
veterinary importance. Although mostly known for their pivotal role in the transmission of …

Virus–host interactions determine an infection outcome. The Asian lineage of Zika virus
(ZIKV), responsible for the recent epidemics, has fixed a mutation in the NS1 gene after …

Summary The Asian lineage of Zika virus (ZIKV) has recently caused epidemics and severe
disease. Unraveling the mechanisms causing increased viral transmissibility and disease …

Flaviviruses such as dengue, yellow fever, Zika, West Nile, and Japanese encephalitis virus
present substantial global health burdens. New vaccines are being sought to address safety …

Japanese encephalitis is a neuropathological disorder caused by Japanese encephalitis
virus (JEV), which is characterized by severe pathological neuroinflammation and damage …

The group of Insect-specific viruses (ISVs) includes viruses apparently restricted to insects
based on their inability to replicate in the vertebrates. Increasing numbers of ISVs have been …

Most viruses in the genus Flavivirus are horizontally transmitted between hematophagous
arthropods and vertebrate hosts, but some are maintained in arthropod-or vertebrate …

Untranslated regions (UTRs) of flaviviruses contain a large number of RNA structural
elements involved in mediating the viral life cycle, including cyclisation, replication, and …