The two most common vestibular disorders are motion sickness and vestibular migraine,
affecting 30 and 1–2% of the population respectively. Both are related to migraine and show …

Hearing loss (HL) is the most prevalent sensory defect affecting 1 in 500 neonates. Genetic
factors are involved in half of the cases. The extreme heterogeneity of HL makes it difficult to …

Hearing loss with enlargement of the vestibular aqueduct (EVA) can be associated with
mutations of the SLC26A4 gene encoding pendrin, a transmembrane Cl−/I−/HCO …

Conclusion. This genetic epidemiological study demonstrated that 26.65% of the prelingual
deafness in Northern Chinese patients can be detected at younger ages by genetic testing …

Deafness is an etiologically heterogeneous trait with many known genetic, environmental
causes or a combination thereof. The identification of more than 120 independent genes for …

Mutations of the human SLC26A4/PDS gene constitute the most common cause of
syndromic and nonsyndromic hearing loss. Definition of the SLC26A4 mutation spectrum …

In China, approximately 30,000 babies are born with hearing impairment each year.
However, the molecular factors causing congenital hearing impairment in the Xiamen area …

Pendred syndrome (PS) and DFNB4, a non-syndromic sensorineural hearing loss with
enlargement of the vestibular aqueduct (EVA), are caused by mutations in the SLC26A4 …

Nonsyndromic autosomal recessive deafness accounts for 80% of hereditary deafness. To
date, 52 loci responsible for autosomal recessive deafness have been mapped and 24 …

Screening pathogenic variants in the SLC26A4 gene is an important part of molecular
genetic testing for hearing loss (HL) since they are one of the common causes of hereditary …