In cerebral ischemia survival of neurons, astrocytes, oligodendrocytes and endothelial cells
is threatened during energy deprivation and/or following re-supply of oxygen and glucose …

The use of hypothermia to mitigate cerebral ischemic injury is not new. From early studies, it
has been clear that cooling is remarkably neuroprotective when applied during global or …

Zinc is present in presynaptic nerve terminals throughout the mammalian central nervous
system and likely serves as an endogenous signaling substance. However, excessive …

We adapt a mouse global ischemia model to permit rapid induction of ischemia and
reperfusion in conjunction with two-photon imaging to monitor the initial ionic, structural, and …

Abstract The cytokine interleukin‐1 (IL‐1) has been implicated in ischaemic, traumatic and
excitotoxic brain damage. The results presented here reveal novel actions of IL‐1 in the …

The effect of N-methyl-d-aspartate (NMDA) and 2-(aminomethyl) phenylacetic acid/kainate
(AMPA/kainate) glutamate receptors on dentate cell proliferation and hippocampal synapsin …

Pyruvate has a remarkable protective effect against zinc neurotoxicity. Because zinc
neurotoxicity is likely one of the key mechanisms of ischemic brain injury, the …

Amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors are assembled from the
four subunits GluR1, 2, 3, 4 (or GluRA, B, C, D). AMPA channels that do not contain the …

Excitotoxicity has been implicated as a mechanism of neuronal death in acute and chronic
neurologic diseases. Cerebral ischemia, head and spinal cord injury, and prolonged seizure …

Synaptic release of Zn2+ and its translocation into postsynaptic neurons probably contribute
to neuronal injury after ischemia or epilepsy. Studies in cultured neurons have revealed that …