Biomedical applications of copper-free click chemistry: in vitro, in vivo, and ex vivo

E Kim, H Koo - Chemical science, 2019 - pubs.rsc.org
Recently, click chemistry has provided important advances in biomedical research fields.
Particularly, copper-free click chemistry including strain-promoted azide–alkyne …

Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy

HM Meng, H Liu, H Kuai, R Peng, L Mo… - Chemical Society …, 2016 - pubs.rsc.org
The combination of nanostructures with biomolecules leading to the generation of functional
nanosystems holds great promise for biotechnological and biomedical applications. As a …

Acid-resistant and physiological pH-responsive DNA hydrogel composed of A-motif and i-motif toward oral insulin delivery

Y Hu, S Gao, H Lu, JY Ying - Journal of the American Chemical …, 2022 - ACS Publications
An acid-resistant DNA hydrogel that is stable in an extremely acidic environment with pH as
low as 1.2 has not been reported before, largely due to the instability of DNA-hybridized …

Spinal cord tissue engineering via covalent interaction between biomaterials and cells

W Liu, B Xu, S Zhao, S Han, R Quan, W Liu, C Ji… - Science …, 2023 - science.org
Noncovalent interactions between cells and environmental cues have been recognized as
fundamental physiological interactions that regulate cell behavior. However, the effects of …

Oligonucleotide aptamers: new tools for targeted cancer therapy

H Sun, X Zhu, PY Lu, RR Rosato, W Tan… - Molecular Therapy-Nucleic …, 2014 - cell.com
Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-
stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar …

Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance

M Ashrafizadeh, H Saebfar, MH Gholami… - Expert opinion on …, 2022 - Taylor & Francis
Introduction The application of doxorubicin (DOX) in cancer therapy has been limited due to
its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the …

Cell-membrane-anchored DNA nanoplatform for programming cellular interactions

J Li, K Xun, K Pei, X Liu, X Peng, Y Du… - Journal of the …, 2019 - ACS Publications
Cell–cell interactions are mediated through compositions expressed on the membrane.
Engineering the cell surface to display functional modules with high biocompatibility, high …

Equipping natural killer cells with specific targeting and checkpoint blocking aptamers for enhanced adoptive immunotherapy in solid tumors

D Zhang, Y Zheng, Z Lin, X Liu, J Li… - Angewandte …, 2020 - Wiley Online Library
Herein, we propose an aptamer‐equipping strategy to generate specific, universal and
permeable (SUPER) NK cells for enhanced immunotherapy in solid tumors. NK cells were …

Cell surface engineering using DNAzymes: metal ion mediated control of cell–cell interactions

RC Qian, ZR Zhou, W Guo, Y Wu… - Journal of the American …, 2021 - ACS Publications
Regulating cell–cell interactions and cell behaviors via cell surface engineering is of
significance for biological research such as cell fate control and cell therapy. While …

Aptamer-functionalized exosomes: elucidating the cellular uptake mechanism and the potential for cancer-targeted chemotherapy

J Zou, M Shi, X Liu, C Jin, X Xing, L Qiu… - Analytical …, 2019 - ACS Publications
Exosomes (Exos) are nanoscale natural vehicles for transporting biomolecules to facilitate
cell-to-cell communication, indicating a high potential of them for delivering therapeutics …