In light of the outbreak of the 2019 novel coronavirus disease (COVID-19), the international
scientific community has joined forces to develop effective treatment strategies. The …

Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and …

Immune checkpoint blockade, exemplified by antibodies targeting the PD-1 receptor, can
induce durable tumor regressions in some patients. To enhance the efficacy of existing …

Simple Summary Natural killer T (NKT) cells are a subset of lipid-reactive T cells that
enhance anti-tumor immunity. While preclinical studies have shown NKT cell …

CXCL16 is a chemotactic cytokine belonging to the α-chemokine subfamily. It plays a
significant role in the progression of cancer, as well as the course of atherosclerosis, renal …

Today, cancer treatment is one of the fundamental problems facing clinicians and
researchers worldwide. Efforts to find an excellent way to treat this illness continue, and new …

Background Glioblastoma (GBM) is the most aggressive type of primary brain tumor and is
often resistant to current therapies. Tumor microenvironment-centered therapies may …

Pro-inflammatory CD4+ T helper (Th) cells drive the pathogenesis of many autoimmune
conditions. Recent advances have modified views of the phenotype of pro-inflammatory Th …

Chemotherapy prior to immune checkpoint blockade (ICB) treatment appears to improve ICB
efficacy but resistance to ICB remains a clinical challenge and is attributed to highly plastic …

Background Oncolytic viruses reduce tumor burden in animal models and have generated
promising results in clinical trials. However, it is likely that oncolytic viruses will be more …