Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling
metabolites whose versatile modes of action are being increasingly appreciated. These …

From the early precipitation-based techniques, introduced more than a century ago, to the
latest development of enzymatic bio-and nano-sensor applications, the analysis of phytic …

The analysis of myo-inositol phosphates (InsPs) and myo-inositol pyrophosphates (PP-
InsPs) is a daunting challenge due to the large number of possible isomers, the absence of …

Circulating phosphate levels are tightly controlled within a narrow range in mammals. By
using a novel small-molecule inhibitor, we show that the enzymatic activity of inositol …

Technical challenges have to date prevented a complete profiling of the levels of myo-
inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we …

Phosphorylation is the most common module of cellular signalling pathways. The dynamic
nature of phosphorylation, which is conferred by the balancing acts of kinases and …

Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7)
are inositol metabolites containing high-energy phosphoanhydride bonds. Biosynthesis of …

Inositol phosphate encompasses a large multifaceted family of signalling molecules that
originate from the combinatorial attachment of phosphate groups to the inositol ring. To date …

Research on extracellular vesicles (EVs) has been expanded, especially in the field of
cancer. The cargoes in EVs, especially those in small EVs such as exosomes include …

Inositol phosphates (InsPs) are ubiquitous in all eukaryotes. However, since there are 63
possible different phosphate ester isomers, the analysis of InsPs is challenging. In particular …