Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Caffeine is the most widely used psychostimulant in Western countries, with antioxidant, anti‐
inflammatory and anti‐apoptotic properties. In Alzheimer's disease (AD), caffeine is …

Purinergic signalling, ie ATP as an extracellular signalling molecule and cotransmitter in
both peripheral and central neurons, is involved in the physiology of neurotransmission and …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of unknown cause.
Absence of specific targets and biomarkers compromise the development of new therapeutic …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
motor neuron (MN) loss. Recent evidences highlight astrocytes as important players in MN …

The mammalian neuromuscular junction (NMJ) comprises a presynaptic terminal, a
postsynaptic receptor region on the muscle fiber (endplate), and the perisynaptic (terminal) …

Denervation of the neuromuscular junction (NMJ) precedes the loss of motor neurons (MNs)
in amyotrophic lateral sclerosis (ALS). ALS is characterized by a motor unit (MU)-dependent …

Astrocytes are major contributors of motor neuron (MN) degeneration in amyotrophic lateral
sclerosis (ALS). We investigated whether regional and cell maturation differences influence …

By signalling through purinergic receptors classified as ionotropic P2X (for ATP) and
metabotropic P1 (for adenosine) and P2Y (mainly for ADP, UDP, UTP, ATP), the …

The vertebrate neuromuscular junction (NMJ) is a specialised chemical synapse involved in
the transmission of bioelectric signals between a motor neuron and a skeletal muscle fiber …