The synapsins are a family of neuronal phosphoproteins evolutionarily conserved in
invertebrate and vertebrate organisms. Their best-characterised function is to modulate …

Neurons can sustain high rates of synaptic transmission without exhausting their supply of
synaptic vesicles. This property relies on a highly efficient local endocytic recycling of …

Neuronal communication crucially relies on exocytosis of neurotransmitters from synaptic
vesicles (SVs) which are clustered at synapses. To ensure reliable neurotransmitter release …

Exosomes are derived from limiting membranes of MVBs (multivesicular bodies). They carry
and transfer selected membrane and cytoplasmic proteins, mRNA and microRNA into target …

Vesicle fusion is executed via formation of an Ω-shaped structure (Ω-profile), followed by
closure (kiss-and-run) or merging of the Ω-profile into the plasma membrane (full fusion) …

Dynamin superfamily proteins (DSPs) mediate membrane fission and fusion necessary for
endocytosis, organelle biogenesis and maintenance, as well as for bacterial cytokinesis …

Presynaptic terminals are specialized compartments of neurons responsible for converting
electrical signals into secreted chemicals. This self-renewing process of chemical synaptic …

Genetic studies have demonstrated that conditional ablation of core autophagy genes in the
neural lineage leads to progressive neurodegeneration, indicating that this catabolic …

Liquid-liquid phase separation is an increasingly recognized mechanism for
compartmentalization in cells. Recent in vitro studies suggest that this organizational …

Phase separation in the cytoplasm is emerging as a major principle in intracellular
organization. In this process, sets of macromolecules assemble themselves into liquid …