Inhaled drug therapy for treatment of tuberculosis

A Misra, AJ Hickey, C Rossi, G Borchard, H Terada… - Tuberculosis, 2011 - Elsevier
The lungs have received attention as a portal for drug delivery in tuberculosis (TB) from
researchers addressing diverse objectives. These include:(a) targeting alveolar …

Nanotherapeutics for pulmonary drug delivery: An emerging approach to overcome respiratory diseases

E Kole, K Jadhav, N Shirsath, P Dudhe… - Journal of Drug Delivery …, 2023 - Elsevier
Pulmonary diseases pose an immense threat to global health. Several nanotherapeutics-
based approaches aimed to tackle pulmonary ailments in recent years. The current …

Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats

L Wang, L Wang, W Ding… - Journal of nanoscience …, 2010 - ingentaconnect.com
We investigated the toxic effects of inhalation exposure to ferric oxide (Fe2O3) and zinc
oxide (ZnO) nanoparticles in rats. Male Wistar rats were consecutively treated with Fe2O3 at …

Dynamic mucus penetrating microspheres for efficient pulmonary delivery and enhanced efficacy of host defence peptide (HDP) in experimental tuberculosis

A Sharma, K Vaghasiya, P Gupta, AK Singh… - Journal of controlled …, 2020 - Elsevier
Pulmonary drug delivery system is increasingly gaining popularity for several lung diseases
including tuberculosis (TB) due to its ability to attain high drug concentrations at the site of …

Hybrid Ofloxacin/eugenol co-loaded solid lipid nanoparticles with enhanced and targetable antimicrobial properties

B Rodenak-Kladniew, SS Montoto… - International journal of …, 2019 - Elsevier
In the global context of an imminent emergence of multidrug-resistant microorganisms, the
present work combined the use of nanotechnology and the therapeutic benefits of natural …

Intracellular time course, pharmacokinetics, and biodistribution of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to mice

RK Verma, J Kaur, K Kumar, AB Yadav… - Antimicrobial agents …, 2008 - Am Soc Microbiol
Intracellular concentrations of isoniazid and rifabutin resulting from administration of
inhalable microparticles of these drugs to phorbol-differentiated THP-1 cells and the …

Targeted delivery of the metastasis-specific tumour homing TMTP1 peptide to non-small-cell lung cancer (NSCLC) using inhalable hybrid nano-assemblies

E Ray, K Jadhav, M Kadian, G Sharma… - Journal of Materials …, 2024 - pubs.rsc.org
Lung cancer is one of the most fatal malignancies, with the highest death rate (∼ 19%), and
the NSCLC type accounts for∼ 85% of lung cancers. In the search for new treatments …

Inhaled microparticles containing clofazimine are efficacious in treatment of experimental tuberculosis in mice

RK Verma, WA Germishuizen, MP Motheo… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Inhalable clofazimine-containing dry powder microparticles (CFM-DPI) and native
clofazimine (CFM) were evaluated for activity against Mycobacterium tuberculosis in human …

Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery

MS Miranda, MT Rodrigues, RMA Domingues… - Materials Science and …, 2018 - Elsevier
The growing interest on polymeric delivery systems for pulmonary administration of drugs
anticipates a more direct and efficient treatment of diseases such as tuberculosis (TB) that …

Comparative Preclinical Pharmacokinetics and Disposition of Favipiravir Following Pulmonary and Oral Administration as Potential Adjunct Therapy Against Airborne …

VSR Devireddy, H Shafi, S Verma, S Singh… - Pharmaceutical …, 2024 - Springer
Background Favipiravir is administered orally, even against airborne RNA viruses, in a
loading-dose/maintenance dose regimen. We investigated whether—(a) pulmonary delivery …