The Hedgehog (Hh) signaling pathway is of central importance during embryo development
in metazoans and governs a diverse array of processes including cell proliferation …

BCOR is a gene that encodes for an epigenetic regulator involved in the specification of cell
differentiation and body structure development and takes part in the noncanonical polycomb …

Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L‑type; R‑type; N‑
type; P/Q‑type; and T‑type, which are encoded by α1 subunit genes. Calcium ion channels …

In Europe, almost 1000 children are diagnosed with a malignant renal tumour each year.
The vast majority of cases are nephroblastoma, also known as Wilms' tumour (WT). Most …

Importance of the field: Sulf-1 and Sulf-2 are sulfatases that edit the sulfation status of
heparan sulfate proteoglycans (HSPGs) on the outside of cells and regulate a number of …

The X-linked BCL-6 co-repressor (BCOR) gene encodes a key constituent of a variant
polycomb repressive complex (PRC) that is mutated or translocated in human cancers. Here …

The mammalian kidney, the metanephros, is a mesodermal organ classically regarded as
arising from the intermediate mesoderm (IM). Indeed, both the ureteric bud (UB), which gives …

Voltage-gated calcium channels (VGCCs) are well documented to play roles in cell
proliferation, migration, and apoptosis; however, whether VGCCs regulate the onset and …

Six1 is a developmentally regulated homeoprotein with limited expression in most normal
adult tissues and frequent misexpression in a variety of malignancies. Here we demonstrate …

The HtrA proteases degrade damaged proteins and thus control the quality of proteins and
protect cells against the consequences of various stresses; they also recognize specific …