Pyoverdine biosynthesis and secretion in Pseudomonas aeruginosa: implications for metal homeostasis

IJ Schalk, L Guillon - Environmental microbiology, 2013 - Wiley Online Library
Pyoverdines are siderophores produced by fluorescent P seudomonads to acquire iron. At
least 60 different pyoverdines produced by diverse strains have been chemically …

Role of iron uptake systems in Pseudomonas aeruginosa virulence and airway infection

F Minandri, F Imperi, E Frangipani, C Bonchi… - Infection and …, 2016 - Am Soc Microbiol
Pseudomonas aeruginosa is a leading cause of hospital-acquired pneumonia and chronic
lung infections in cystic fibrosis patients. Iron is essential for bacterial growth, and P …

High affinity iron uptake by pyoverdine in Pseudomonas aeruginosa involves multiple regulators besides Fur, PvdS, and FpvI

P Cornelis, A Tahrioui, O Lesouhaitier, E Bouffartigues… - Biometals, 2023 - Springer
Pseudomonas aeruginosa is a Gram-negative bacterium which can cause serious infections
among immune-depressed people including cystic fibrosis patients where it can colonize the …

Molecular basis of pyoverdine siderophore recycling in Pseudomonas aeruginosa

F Imperi, F Tiburzi, P Visca - Proceedings of the National …, 2009 - National Acad Sciences
The siderophore pyoverdine (PVD) is a primary virulence factor of the human pathogenic
bacterium Pseudomonas aeruginosa, acting as both an iron carrier and a virulence-related …

Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity

F Imperi, F Massai, M Facchini… - Proceedings of the …, 2013 - National Acad Sciences
Although antibiotic resistance represents a public health emergency, the pipeline of new
antibiotics is running dry. Repurposing of old drugs for new clinical applications is an …

Ferric uptake regulator Fur is conditionally essential in Pseudomonas aeruginosa

M Pasqua, D Visaggio, A Lo Sciuto, S Genah… - Journal of …, 2017 - Am Soc Microbiol
In Pseudomonas aeruginosa, the ferric uptake regulator (Fur) protein controls both
metabolism and virulence in response to iron availability. Differently from other bacteria …

Gallium-Protoporphyrin IX Inhibits Pseudomonas aeruginosa Growth by Targeting Cytochromes

S Hijazi, P Visca, E Frangipani - Frontiers in cellular and infection …, 2017 - frontiersin.org
Pseudomonas aeruginosa is a challenging pathogen due to both innate and acquired
resistance to antibiotics. It is capable of causing a variety of infections, including chronic lung …

Synthesis of the siderophore pyoverdine in Pseudomonas aeruginosa involves a periplasmic maturation

E Yeterian, LW Martin, L Guillon, L Journet, IL Lamont… - Amino acids, 2010 - Springer
Pyoverdines, the main siderophores produced by fluorescent Pseudomonads, comprise a
fluorescent dihydroxyquinoline chromophore attached to a strain-specific peptide. These …

RsaL-driven negative regulation promotes heterogeneity in Pseudomonas aeruginosa quorum sensing

M Mellini, M Letizia, L Caruso, A Guiducci… - Mbio, 2023 - Am Soc Microbiol
In its canonical interpretation, quorum sensing (QS) allows single cells in a bacterial
population to synchronize gene expression and hence perform specific tasks collectively …

Cellular organization of siderophore biosynthesis in Pseudomonas aeruginosa: Evidence for siderosomes

V Gasser, L Guillon, O Cunrath, IJ Schalk - Journal of inorganic …, 2015 - Elsevier
Pyoverdine I (PVDI) and pyochelin (PCH) are the two major siderophores produced by
Pseudomonas aeruginosa PAO1 to import iron. The biochemistry of the biosynthesis of …