The predictable nature of DNA interactions enables the programmable assembly of highly
advanced 2D and 3D DNA structures of nanoscale dimensions. The access to ever larger …

Highlights•New assembly approaches of DNA nanostructures with increased complexity.•
Biotechnological approaches for improved scalability of DNA assembly.•Blunt-end stacking …

Nucleic acid amphiphiles, referring to nucleic acids modified with large hydrophobic groups,
have been widely used in programmable bioengineering. Since nucleic acids are …

We report a spherical nucleic acid (SNA) system for the delivery of BKM120, an anticancer
drug for treatment of chronic lymphocytic leukemia (CLL). While promising for cancer …

Abstract Two‐dimensional (2D) assemblies of water‐soluble block copolymers have been
limited by a dearth of systematic studies that relate polymer structure to pathway mechanism …

Gene therapy is a therapeutic option for mitigating diseases that do not respond well to
pharmacological therapy. This type of therapy allows for correcting altered and defective …

The translation of well-established molecular biology methods such as genetic coding,
selection, and DNA sequencing to combinatorial organic chemistry and compound …

As colloidal self-assembly increasingly approaches the complexity of natural systems, an
ongoing challenge is to generate non-centrosymmetric structures. For example, patchy …

Supramolecular one-dimensional (1D) architectures are of high interest in drug delivery and
templation of complex linear arrays due to their high aspect ratio and rigidity. A particular …

RNA can serve as powerful building blocks for bottom-up fabrication of nanostructures for
biotechnological and biomedical applications. In addition to current self-assembly strategies …