Oxidative stability in lipid formulations: a review of the mechanisms, drivers, and inhibitors of oxidation

J Musakhanian, JD Rodier, M Dave - AAPS PharmSciTech, 2022 - Springer
The importance of lipid-based formulations in addressing solubility and ultimately the
bioavailability issues of the emerging drug entities is undeniable. Yet, there is scarcity of …

Potential lipid-based strategies of amphotericin B designed for oral administration in clinical application

X Zhong, J Yang, H Liu, Z Yang, P Luo - Drug Delivery, 2023 - Taylor & Francis
Amphotericin B (AmB) is regarded as a first-line therapy against life-threatening invasive
fungal infections. Due to its poor oral bioavailability, AmB is restricted to intravenous …

Preparation and evaluation of diosmin-loaded diphenylcarbonate-cross-linked cyclodextrin nanosponges for breast cancer therapy

MK Anwer, MM Ahmed, MF Aldawsari, M Iqbal… - Pharmaceuticals, 2022 - mdpi.com
In the current study, diosmin (DSM)-loaded beta-cyclodextrin (β-CD)-based nanosponges
(NSPs) using diphenylcarbonate (DPC) as a cross-linker were prepared. Four different DSM …

Review of novel oral amphotericin B formulations for the treatment of parasitic infections

E Wasan, T Mandava, P Crespo-Moran, A Nagy… - Pharmaceutics, 2022 - mdpi.com
Amphotericin B (AmpB) is a polyene macrolide antibiotic used in the treatment of blood-
borne parasitic and fungal infections. However, its use, particularly in the developing world …

Exploring the role of self-nanoemulsifying systems in drug delivery: challenges, issues, applications and recent advances

R Verma, V Mittal, P Pandey, S Bhatia… - Current Drug …, 2023 - ingentaconnect.com
Nanotechnology has attracted researchers around the globe owing to the small size and
targeting properties of the drug delivery vectors. The interest in self-nanoemulsifying drug …

Self-nanoemulsifying drug delivery system (SNEDDS) of docetaxel and carvacrol synergizes the anticancer activity and enables safer toxicity profile: optimization, and …

MAM Ateeq, M Aalhate, S Mahajan, GS Kumar… - Drug Delivery and …, 2023 - Springer
Docetaxel (DTX) is a first-line chemotherapeutic molecule with a broad-spectrum anticancer
activity. On the other hand, carvacrol (CV) has anti-inflammatory, antioxidant, cytotoxic, and …

Conjugates of amphotericin B to resolve challenges associated with its delivery

VK Jain, K Jain, H Popli - Expert Opinion on Drug Delivery, 2024 - Taylor & Francis
ABSTRACT Introduction Amphotericin B (AmB), a promising antifungal and antileishmanial
drug, acts on the membrane of microorganisms. The clinical use of AmB is limited due to …

Solid Self Nano-Emulsifying Drug Delivery System of Dasatinib: Optimization, In-vitro, Ex-vivo and In-vivo assessment

MA Mohd Ateeq, S Mahajan, BN Saren… - Therapeutic …, 2024 - Taylor & Francis
Aim: Dasatinib (DST) is an oral tyrosine kinase inhibitor with poor aqueous solubility. To
outwit this issue, a solid self-nano emulsifying drug delivery system (S-SNEDDS) of DST …

Limitations of current chemotherapy and future of nanoformulation-based AmB delivery for visceral leishmaniasis—An updated review

P Kumar, P Kumar, N Singh, S Khajuria… - … in Bioengineering and …, 2022 - frontiersin.org
Visceral leishmaniasis (VL) is the most lethal of all leishmaniasis diseasesand the second
most common parasiticdisease after malaria and, still, categorized as a neglected tropical …

Self-Nanoemulsifying Formulation Improves Oral Bioavailability and Insulin Sensitizing Potency of Formononetin–Vitamin E Conjugate in Type 2 Diabetic Mice

RK Dhritlahre, N Thakur, A Goel, V Patial… - Molecular …, 2024 - ACS Publications
The escalating incidence of obesity, diabetes, and insulin resistance has become a
significant global health concern. In this study, we have developed a self-nanoemulsifying …