The aryl hydrocarbon receptor (AhR) is a transcriptional factor that regulates multiple
functions following its activation by a variety of ligands, including xenobiotics, natural …

The antagonistic pleiotropy hypothesis is a well-known evolutionary theory to explain the
aging process. It proposes that while a particular gene may possess beneficial effects during …

Gut microbiota alterations might affect the development of Alzheimer's disease (AD) through
microbiota-derived metabolites. For example, microbiota-derived Indoles via tryptophan …

Major depressive disorder (MDD) is associated with premature mortality and is an
independent risk factor for a broad range of diseases, especially those associated with …

In recent years, aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, has
been considered to be involved in aging phenotypes across several species. This receptor …

The gut is an important organ with digestive and immune regulatory function which
consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to …

Aging is the most important risk factor for the development of major life-threatening diseases
such as cardiovascular disorders, cancer, and neurodegenerative disorders. The aging …

Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …

The tryptophan metabolite kynurenine increases with aging and inflammation, and appears
to contribute directly to the development and progression of several age-related conditions …

Background and Purpose Increasing evidence has indicated that the high risk of
cardiovascular disease in chronic kidney disease (CKD) patients cannot be sufficiently …