Antibacterial and antifungal alkaloids from Asian angiosperms: Distribution, mechanisms of action, structure-activity, and clinical potentials

M Sulaiman, K Jannat, V Nissapatorn, M Rahmatullah… - Antibiotics, 2022 - mdpi.com
The emergence of multidrug-resistant bacteria and fungi requires the development of
antibiotics and antifungal agents. This review identified natural products isolated from Asian …

Design, synthesis, and antifungal activity of novel thiophene/furan-1, 3, 4-oxadiazole carboxamides as potent succinate dehydrogenase inhibitors

Z Yang, Y Sun, Q Liu, A Li, W Wang… - Journal of Agricultural …, 2021 - ACS Publications
Succinate dehydrogenase (SDH) is known as an ideal target for the investigations of
fungicides. To develop novel SDH inhibitors, 30 novel thiophene/furan-1, 3, 4-oxadiazole …

Discovery of novel quinazoline-2-aminothiazole hybrids containing a 4-piperidinylamide linker as potential fungicides against the phytopathogenic fungus Rhizoctonia …

M Ding, N Wu, Q Lin, Y Yan, Y Yang… - Journal of Agricultural …, 2022 - ACS Publications
A total of 29 novel quinazoline-2-aminothiazole hybrids containing a 4-piperidinylamide
linker were designed, synthesized, and evaluated for their anti-microbial properties against …

Synthesis, Structural Characterization, and Antibacterial and Antifungal Activities of Novel 1,2,4-Triazole Thioether and Thiazolo[3,2-b]-1,2,4-triazole Derivatives …

M Ding, S Wan, N Wu, Y Yan, J Li… - Journal of Agricultural and …, 2021 - ACS Publications
A total of 52 novel 1, 2, 4-triazole thioether and thiazolo [3, 2-b]-1, 2, 4-triazole derivatives
bearing the 6-fluoroquinazolinyl moiety were designed, synthesized, and evaluated as …

Discovery of N-Phenylpropiolamide as a Novel Succinate Dehydrogenase Inhibitor Scaffold with Broad-Spectrum Antifungal Activity on Phytopathogenic Fungi

YH Zhang, SS Yang, Q Zhang, TT Zhang… - Journal of Agricultural …, 2023 - ACS Publications
Based on the structural features of both succinate dehydrogenase inhibitors (SDHIs) and
targeted covalent inhibitors, a series of N-phenylpropiolamides containing a Michael …

Synthesis, anti-α-glucosidase activity, inhibition interaction, and anti-diabetic activity of novel cryptolepine derivatives

M Feng, B Liang, J Sun, X Min, SH Wang, Y Lu… - Journal of Molecular …, 2024 - Elsevier
To find potential α-glucosidase inhibitors, thirty-seven cryptolepine derivatives (FM1∼ 37)
were designed and synthesized. Compared to parent compound cryptolepine (IC 50 …

Quinoline Derivatives in Discovery and Development of Pesticides

Q Cai, H Song, Y Zhang, Z Zhu, J Zhang… - Journal of Agricultural …, 2024 - ACS Publications
Finding highly active molecular scaffold structures is always the key research content of new
pesticide discovery. In the research and development of new pesticides, the discovery of …

Drug repurposing strategy II: from approved drugs to agri-fungicide leads

JX An, Y Ma, WB Zhao, YM Hu, YR Wang… - The Journal of …, 2023 - nature.com
Epidemic diseases of crops caused by fungi deeply affected the course of human history
and processed a major restriction on social and economic development. However, with the …

Design, synthesis, and antimicrobial activity of quindoline derivatives inspired by the cryptolepine alkaloid

QR Chu, YH He, C Tang, ZJ Zhang… - Journal of Agricultural …, 2022 - ACS Publications
Based on the structural characteristics of the cryptolepine alkaloid, a series of new
quindoline derivatives bearing various substituents were prepared and evaluated for their …

Fabrication of CuO nanoparticles composite ε-polylysine-alginate nanogel for high-efficiency management of Alternaria alternate

X Zhu, X Ma, C Gao, Y Mu, Y Pei, C Liu, A Zou… - International Journal of …, 2022 - Elsevier
Although ε-poly-l-lysine (ε-PL) has a good potential as a green fungicide, high concentration
is usually required during its controlling of plant disease. On the other hand, same problems …