Recent advances in lipid-based long-acting injectable depot formulations

R Sharma, S Yadav, V Yadav, J Akhtar, O Katari… - Advanced drug delivery …, 2023 - Elsevier
Long-acting injectable (LAIs) delivery systems sustain the drug therapeutic action in the
body, resulting in reduced dosage regimen, toxicity, and improved patient compliance. Lipid …

Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges

V Agrahari, SM Anderson, MM Peet… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Poor or inconsistent adherence to daily oral pre-exposure prophylaxis (PrEP)
has emerged as a key barrier to effective HIV prevention. The advent of potent long-acting …

[HTML][HTML] Advances in long-acting slow effective release antiretroviral therapies for treatment and prevention of HIV infection

MU Nayan, B Sillman, M Hasan, S Deodhar… - Advanced Drug Delivery …, 2023 - Elsevier
Adherence to daily oral antiretroviral therapy (ART) is a barrier to both treatment and
prevention of human immunodeficiency virus (HIV) infection. To overcome limitations of life …

Oral drug delivery: conventional to long acting new-age designs

U Bhutani, T Basu, S Majumdar - European Journal of Pharmaceutics and …, 2021 - Elsevier
The Oral route of administration forms the heartwood of the ever-growing tree of drug
delivery technology. It is one of the most preferred dosage forms among patients and …

Lipid–drug conjugates and associated carrier strategies for enhanced antiretroviral drug delivery

F Takalani, P Kumar, PPD Kondiah… - Pharmaceutical …, 2020 - Taylor & Francis
Mortality rate of patients infected with HIV-1 has been significantly reduced by using HAART.
However, the virus to date has not been eradicated. Transmission of HIV-1 infection through …

[HTML][HTML] Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable In Situ Cross-Linked Depots

S Lee, S Zhao, W Jiang, X Chen, L Zhu, J Joseph… - …, 2024 - pmc.ncbi.nlm.nih.gov
Achieving ultra-long-term release of hydrophilic drugs over several months remains a
significant challenge for existing long-acting injectables (LAIs). Existing platforms, such as in …

A New Approach to Developing Long-Acting Injectable Formulations of Anti-HIV Drugs: Poly (Ethylene Phosphoric Acid) Block Copolymers Increase the Efficiency of …

I Nifant'ev, A Siniavin, E Karamov, M Kosarev… - International Journal of …, 2020 - mdpi.com
Despite the world's combined efforts, human immunodeficiency virus (HIV), the causative
agent of AIDS, remains one of the world's most serious public health challenges. High …

Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable In Situ Cross-Linked Depots

S Lee, S Zhao, W Jiang, X Chen, L Zhu, J Joseph… - bioRxiv, 2023 - biorxiv.org
Although hydrophilic drugs represent a large proportion of all therapeutics used to treat and
manage chronic diseases, achieving their ultra-long-term delivery via an injectable system …