Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …

Despite concerted international efforts, mortality from neonatal infections remains
unacceptably high in some areas of the world, particularly for premature infants. Recent …

Genome-wide methylation arrays are powerful tools for assessing cell composition of
complex mixtures. We compare three approaches to select reference libraries for …

In mammals, caloric restriction consistently results in extended lifespan. Epigenetic
information encoded by DNA methylation is tightly regulated, but shows a striking drift …

Motivation DNA methylation datasets are growing ever larger both in sample size and
genome coverage. Novel computational solutions are required to efficiently handle these …

Epigenome-wide association studies of disease widely use DNA methylation measured in
blood as a surrogate tissue. Cell proportions can vary between people and confound …

Background Gestational age is often used as a proxy for developmental maturity by
clinicians and researchers alike. DNA methylation has previously been shown to be …

Motivation Ageing is a biological and psychosocial process related to diseases and
mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues …

Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and
later in life. Individual studies have shown that epigenetic modifications such as DNA …

Background DNA methylation (DNAm) profiling has emerged as a powerful tool for
characterizing the placental methylome. However, previous studies have focused primarily …