Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …

Despite the recent progress in cancer management approaches, the mortality rate of cancer
is still growing and there are lots of challenges in the clinics in terms of novel therapeutics …

Although angiotensin II (AngII) is known to cause renal injury and fibrosis, the underlying
mechanisms remain poorly characterized. Here we show that hypertensive nephropathy …

In the light of growing global epidemic of type 2 diabetes mellitus (T2DM), significant efforts
are made to discover next-generation biomarkers for early detection of the disease. Multiple …

Abstract Chitinase 3-like 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation,
macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is …

Abstract Chitinase‐3‐like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its
ability to regulate multiple biological processes, such as the inflammatory response and …

The diabetic heart is characterized by metabolic disturbances that are often accompanied by
local inflammation, oxidative stress, myocardial fibrosis, and cardiomyocyte apoptosis …

Hyperglycaemia can strongly alter the epigenetic signatures in many types of human
vascular cells providing persistent perturbations of protein–protein interactions both in micro …

Background Type 2 diabetes mellitus (T2DM) is an increasing metabolic disorder mostly
resulting from unhealthy lifestyles. T2DM patients are prone to develop heart conditions …

MicroRNAs (miRs, miRNAs) are regulatory small noncoding RNAs, with their roles already
confirmed to be important for post-transcriptional regulation of gene expression affecting cell …