Based on our work and that of many other workers, we have developed a model of
coagulation in vivo. Many workers have demonstrated mechanisms by which cells can …

Extracellular endogenous proteases, as well as exogenous proteases from mites and molds,
react with cell-surface receptors in the airways to generate leukocyte infiltration and to …

The mortality and neurological morbidity in heatstroke have been attributed to the host's
inflammatory and hemostatic responses to heat stress, suggesting that immunomodulation …

Objective To determine the cellular origin of synovial microparticles, their procoagulant
properties, and their relationship to local hypercoagulation. Methods Microparticles in …

Thrombosis is the defining feature of the most prevalent causes of cardiovascular mortality,
such as myocardial infarction, stroke, and pulmonary artery embolism. Although platelet …

Malaria remains a highly prevalent disease in more than 90 countries and accounts for at
least 1 million deaths every year. Plasmodium falciparum infection is often associated with a …

Proinflammatory effects induced by the serine protease factor Xa were investigated in
HUVEC. Exposure of cells to factor Xa (5–80 nM) concentration dependently stimulated the …

Disseminated intravascular coagulation (DIC) is characterized by the in vivo activation of the
coagulation system, which results in the intravascular deposition of fibrin and consumption …

Survivin is a member of the inhibitor of apoptosis protein (IAP) family that is believed to play
a role in oncogenesis. To elucidate further its physiologic role (s), we have characterized the …

Aim. Thrombin not only plays a central role in thrombus formation and platelet activation, but
also in induction of inflammatory processes. Activated factor X (FXa) is traditionally known as …