Insect prophenoloxidase: the view beyond immunity

A Lu, Q Zhang, J Zhang, B Yang, K Wu, W Xie… - Frontiers in …, 2014 - frontiersin.org
Insect prophenoloxidase (PPO) is an important innate immunity protein due to its
involvement in cellular and humoral defense. It belongs to a group of type-3 copper …

Insect hemolymph immune complexes

KD Clark - … and invertebrate respiratory proteins, lipoproteins and …, 2020 - Springer
Insects possess powerful immune systems that have evolved to defend against wounding
and environmental pathogens such as bacteria, fungi, protozoans, and parasitoids. This …

Reproductive arrest and stress resistance in winter-acclimated Drosophila suzukii

J Toxopeus, R Jakobs, LV Ferguson, TD Gariepy… - Journal of insect …, 2016 - Elsevier
Overwintering insects must survive the multiple-stress environment of winter, which includes
low temperatures, reduced food and water availability, and cold-active pathogens. Many …

High throughput profiling of the cotton bollworm Helicoverpa armigera immunotranscriptome during the fungal and bacterial infections

GH Xiong, LS Xing, Z Lin, TT Saha, C Wang, H Jiang… - BMC genomics, 2015 - Springer
Background Innate immunity is essential in defending against invading pathogens in
invertebrates. The cotton bollworm, Helicoverpa armigera (Hübner) is one of the most …

Hindgut innate immunity and regulation of fecal microbiota through melanization in insects

Q Shao, B Yang, Q Xu, X Li, Z Lu, C Wang… - Journal of biological …, 2012 - ASBMB
Many insects eat the green leaves of plants but excrete black feces in an as yet unknown
mechanism. Insects cannot avoid ingesting pathogens with food that will be specifically …

A M35 family metalloprotease is required for fungal virulence against insects by inactivating host prophenoloxidases and beyond

A Huang, M Lu, E Ling, P Li, C Wang - Virulence, 2020 - Taylor & Francis
ABSTRACT A diverse family of metalloproteases (MPs) is distributed in eukaryotes.
However, the functions of MPs are still understudied. We report that seven MPs belonging to …

Immune responses to Bacillus thuringiensis in the midgut of the diamondback moth, Plutella xylostella

J Lin, XQ Yu, Q Wang, X Tao, J Li, S Zhang… - Developmental & …, 2020 - Elsevier
The diamondback moth, Plutella xylostella, is the first insect to develop resistance to Bacillus
thuringiensis (Bt) in the field. To date, little is known about the molecular mechanism of the …

The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche

B Benmimoun, C Polesello… - Proceedings of the …, 2015 - National Acad Sciences
The maintenance of stem or progenitor cell fate relies on intrinsic factors as well as local
cues from the cellular microenvironment and systemic signaling. In the lymph gland, an …

Plant phenolics are detoxified by prophenoloxidase in the insect gut

K Wu, J Zhang, Q Zhang, S Zhu, Q Shao, KD Clark… - Scientific reports, 2015 - nature.com
Plant phenolics are a group of important secondary metabolites that are toxic to many
animals and insects if ingested at high concentrations. Because most insects consume plant …

Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster

Q Jin, Y Wang, H Yin, H Jiang - Frontiers in Immunology, 2023 - frontiersin.org
Insect phenoloxidases (POs) catalyze phenol oxygenation and o-diphenol oxidation to form
reactive intermediates that kill invading pathogens and form melanin polymers. To reduce …