Tumor microenvironment (TME) takes critical roles in tumor resistance to immune checkpoint
inhibitors (ICIs) including anti-programmed death-1 (PD-1) or anti-programmed death-ligand …

Simple Summary Ovarian cancer is a highly lethal female malignancy with high rates of
advanced stage and recurrent disease. Ovarian cancer is characterized as poorly …

Chimeric antigen receptor (CAR) T cell therapies have successfully treated hematological
malignancies. Macrophages have also gained attention as an immunotherapy owing to their …

Background Platinum resistance is a major challenge in the clinical treatment of advanced
ovarian cancer (OC). Accumulating evidence shows that the tumor-promotive M2 …

Ubiquitin (Ub) chain formation by homologous to E6AP C-terminus (HECT)-family E3 ligases
regulates vast biology, yet the structural mechanisms remain unknown. We used chemistry …

UBR5 is a nuclear E3 ligase that ubiquitinates a vast range of substrates for proteasomal
degradation. This HECT domain‐containing ubiquitin ligase has recently been identified as …

Immunotherapy as a rapidly developing therapeutic approach has revolutionized cancer
treatment and revitalized the field of tumor immunology research. 3D in vitro models are …

Ovarian cancer (OC) is one of the most common gynecological malignancies with high
morbidity and mortality. The peritoneum is one of the most common metastatic sites in …

The tumor microenvironment (TME) is the tumor surrounding environment, which is critical
for tumor development and progression. TME is also involved in clinical intervention and …

All eukaryotes require intricate protein networks to translate developmental signals into
accurate cell fate decisions. Mutations that disturb interactions between network …