Vedolizumab is a novel therapeutic monoclonal antibody recently approved for the treatment
of moderately to severely active ulcerative colitis and Crohn's disease in adults who have …

Inflammatory bowel diseases (IBD) are a complex group of diseases involving alterations in
mucosal immunity and gastrointestinal physiology during both initiation and progressive …

We found that mechanical injury to mouse skin, which can be caused by tape stripping,
results in rapid induction of IL-10 mRNA. IL-10–/–mice were used to examine the role of IL …

BACKGROUND & AIMS:: Integrins (α4 and β2) and their endothelial ligands vascular cell
adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) play key …

Adhesion molecule immunoneutralization is envisioned as a promising therapy for
inflammatory bowel disease, but the relative value of selective blockade of different …

Inflammatory bowel disease (IBD) is associated with Th1/Th2 cytokine dysregulation,
leukocyte extravasation, and tissue edema, but the mechanisms for cytokine-mediated …

To determine the role of endogenous IL-10 in local antibacterial host defense and in the
development of a systemic inflammatory response syndrome during abdominal sepsis, IL-10 …

Multiple sclerosis (MS) is the most common of the immune demyelinating disorders of the
central nervous system (C NS). Leukocyte/endothelial interactions are important steps in the …

Canine babesiosis is a tick-borne protozoan disease caused by intraerythrocytic parasites of
the genus Babesia. The infection may lead to anemia in infected dogs. However, anemia is …

Abstract Background and Aims Interleukin 6 [IL-6] or its receptor is currently a candidate for
targeted biological therapy of inflammatory bowel disease [IBD]. Thus, a comprehensive …