The nodes of Ranvier have clustered Na+ and K+ channels necessary for rapid and efficient
axonal action potential conduction. However, detailed mechanisms of channel clustering …

Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Multiple sclerosis (MS) is an inflammatory demyelinating disease that is considered by many
people to have an autoimmune aetiology. In recent years, new data emerging from …

Action potential (AP) propagation in myelinated nerves requires clustered voltage gated
sodium and potassium channels. These channels must be specifically localized to nodes of …

Healthy nodes of Ranvier are crucial for action potential propagation along myelinated
axons, both in the central and in the peripheral nervous system. Surprisingly, the node of …

The efficient propagation of action potentials along nervous fibers is necessary for animals
to interact with the environment with timeliness and precision. Myelination of axons is an …

The hyaluronan and proteoglycanbinding link protein (Hapln) is a key molecule in the
formation and control of hyaluronan-based condensed perineuronal matrix in the adult …

Myelination of axons by oligodendrocytes enables fast saltatory conduction.
Oligodendrocytes are responsive to neuronal activity, which has been shown to induce …

The axon initial segment (AIS) is the site of action potential generation and a locus of activity-
dependent homeostatic plasticity. A multimeric complex of sodium channels, linked via a …