Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer's disease

V Rudajev, J Novotny - Frontiers in molecular neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder that is one of the most
devastating and widespread diseases worldwide, mainly affecting the aging population. One …

[HTML][HTML] Neutron scattering studies on dynamics of lipid membranes

M Nagao, H Seto - Biophysics Reviews, 2023 - pubs.aip.org
Neutron scattering methods are powerful tools for the study of the structure and dynamics of
lipid bilayers in length scales from sub Å to tens to hundreds nm and the time scales from …

Niosomes as Biocompatible Scaffolds for the Multivalent Presentation of Tumor-Associated Antigens (TACAs) to the Immune System

S Fallarini, F Papi, F Licciardi, F Natali… - Bioconjugate …, 2022 - ACS Publications
Fully synthetic tumor-associated carbohydrate antigen (TACA)-based vaccines are a
promising strategy to treat cancer. To overcome the intrinsic low immunogenicity of TACAs …

The Role of Amyloid β‐Biomembrane Interactions in the Pathogenesis of Alzheimer's Disease: Insights from Liposomes as Membrane Models

S Andrade, JA Loureiro, MC Pereira - ChemPhysChem, 2021 - Wiley Online Library
The aggregation and deposition of amyloid β (Aβ) peptide onto neuronal cells, with
consequent cellular membrane perturbation, are central to the pathogenesis of Alzheimer's …

Fusion of raft-like lipid bilayers operated by a membranotropic domain of the HSV-type I glycoprotein gH occurs through a cholesterol-dependent mechanism

G Vitiello, A Falanga, AA Petruk, A Merlino, G Fragneto… - Soft matter, 2015 - pubs.rsc.org
A wealth of evidence indicates that lipid rafts are involved in the fusion of the viral lipid
envelope with the target cell membrane. However, the interplay between these sterol-and …

Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains

MC Nicastro, D Spigolon, F Librizzi, O Moran… - Biophysical …, 2016 - Elsevier
Neuronal membrane damage is related to the early impairments appearing in Alzheimer's
disease due to the interaction of the amyloid β-peptide (Aβ) with the phospholipid bilayer. In …

[HTML][HTML] Revealing cholesterol effects on PEGylated HSPC liposomes using AF4–MALS and simultaneous small-and wide-angle X-ray scattering

TW Hsu, CH Yang, CJ Su, YT Huang… - Journal of Applied …, 2023 - scripts.iucr.org
Liposome development is of great interest owing to increasing requirements for efficient
drug carriers. The structural features and thermal stability of such liposomes are crucial in …

Collective dynamics in model biological membranes measured by neutron spin echo spectroscopy

EG Kelley, PD Butler, M Nagao - Characterization of Biological …, 2019 - degruyter.com
Cell membranes are extraordinarily heterogeneous environments composed of many
thousands of chemically distinct lipids, sterols, and proteins. It is this very complexity and …

Dynamic processes in biological membrane mimics revealed by quasielastic neutron scattering

L Lautner, K Pluhackova, NKH Barth, T Seydel… - Chemistry and physics …, 2017 - Elsevier
Neutron scattering is a powerful tool to study relaxation processes in biological membrane
mimics in space and time. Combining different inelastic and quasielastic neutron scattering …

Amyloid β-Peptide Interaction with Membranes: Can Chaperones Change the Fate?

C Ricci, M Maccarini, P Falus, F Librizzi… - The Journal of …, 2018 - ACS Publications
The understanding of amyloid β-peptide (Aβ) interactions with cellular membranes is a
crucial molecular challenge against Alzheimer's disease. Indeed, Aβ prefibrillar oligomeric …