Immune mechanisms of hypertension
GR Drummond, A Vinh, TJ Guzik… - Nature Reviews …, 2019 - nature.com
Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …
A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme
KE Bernstein, FS Ong, WLB Blackwell, KH Shah… - Pharmacological …, 2013 - Elsevier
Angiotensin-converting enzyme (ACE) is a zinc-dependent peptidase responsible for
converting angiotensin I into the vasoconstrictor angiotensin II. However, ACE is a relatively …
converting angiotensin I into the vasoconstrictor angiotensin II. However, ACE is a relatively …
A historical perspective on ACE2 in the COVID-19 era
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). Lessons learned from severe acute respiratory syndrome …
coronavirus 2 (SARS-CoV-2). Lessons learned from severe acute respiratory syndrome …
A century old renin–angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology
P Balakumar, G Jagadeesh - Cellular signalling, 2014 - Elsevier
Ang II, the primary effector pleiotropic hormone of the renin–angiotensin system (RAS)
cascade, mediates physiological control of blood pressure and electrolyte balance through …
cascade, mediates physiological control of blood pressure and electrolyte balance through …
Angiotensin receptor type 1 and endothelin receptor type A on immune cells mediate migration and the expression of IL-8 and CCL18 when stimulated by …
J Günther, A Kill, MO Becker, H Heidecke… - Arthritis research & …, 2014 - Springer
Abstract Introduction Agonistic autoantibodies (Aabs) against the angiotensin II receptor type
1 (AT1R) and the endothelin receptor type A (ETAR) have been identified in patients with …
1 (AT1R) and the endothelin receptor type A (ETAR) have been identified in patients with …
Immunomodulation and immunopharmacology in heart failure
G Markousis-Mavrogenis, L Baumhove… - Nature Reviews …, 2024 - nature.com
The immune system is intimately involved in the pathophysiology of heart failure. However, it
is currently underused as a therapeutic target in the clinical setting. Moreover, the …
is currently underused as a therapeutic target in the clinical setting. Moreover, the …
[HTML][HTML] Th-17 cell activation in response to high salt following acute kidney injury is associated with progressive fibrosis and attenuated by AT-1R antagonism
P Mehrotra, JB Patel, CM Ivancic, JA Collett… - Kidney international, 2015 - Elsevier
Exposure of rats to elevated dietary salt following recovery from acute kidney injury (AKI)
accelerates the transition to chronic kidney disease (CKD), and is dependent on lymphocyte …
accelerates the transition to chronic kidney disease (CKD), and is dependent on lymphocyte …
The mechanistic overview of SARS-CoV-2 using angiotensin-converting enzyme 2 to enter the cell for replication: possible treatment options related to the renin …
The SARS-CoV-2 pandemic is a healthcare crisis caused by insufficient knowledge
applicable to effectively combat the virus. Therefore, different scientific discovery strategies …
applicable to effectively combat the virus. Therefore, different scientific discovery strategies …
Renin–angiotensin system blockade in the COVID-19 pandemic
In the early months of the coronavirus disease 2019 (COVID-19) pandemic, a hypothesis
emerged suggesting that pharmacologic inhibitors of the renin–angiotensin system (RAS) …
emerged suggesting that pharmacologic inhibitors of the renin–angiotensin system (RAS) …
Transcriptome-based analysis of human peripheral blood reveals regulators of immune response in different viral infections
SM Ivanov, OA Tarasova, VV Poroikov - Frontiers in Immunology, 2023 - frontiersin.org
Introduction There are difficulties in creating direct antiviral drugs for all viruses, including
new, suddenly arising infections, such as COVID-19. Therefore, pathogenesis-directed …
new, suddenly arising infections, such as COVID-19. Therefore, pathogenesis-directed …