Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

Nature is the most abundant source for novel drug discovery. Lycorine is a natural alkaloid
with immense therapeutic potential. Lycorine is active in a very low concentration and with …

Cell death has a fundamental impact on the evolution of degenerative disorders,
autoimmune processes, inflammatory diseases, tumor formation and immune surveillance …

Indolizidine alkaloids are chemical constituents isolated from various marine and terrestrial
plants and animals, including but not limited to trees, fungi, ants, and frogs, with a myriad of …

Lung cancer is the second (11.4%) most commonly diagnosed cancer and the first (18%) to
cause cancer-related deaths worldwide. The incidence of lung cancer varies significantly …

Multiple myeloma (MM) is largely incurable and drug-resistant. Novel therapeutic
approaches such as inhibiting autophagy or rational drug combinations are aimed to …

Breast cancer is the most commonly diagnosed cancer type worldwide among women and
more than 90% of patients die from tumor metastasis. Lycorine, a natural alkaloid, has been …

Modern research has shown that Amaryllidaceae alkaloids represent a rich reservoir of
potential small chemical molecules exhibiting several medicinal properties through various …

While the mechanisms underlying apoptosis and autophagy have been well characterized
over recent decades, another regulated cell death event, necroptosis, remains poorly …

Osteosarcoma (OS) is the most common type of primary bone cancer. Even with advances in
early diagnosis and aggressive treatment, the overall prognosis for OS remains to be further …