In this review we summarize recent major advances in our understanding on the molecular
mechanisms, mediators, and biomarkers of acute lung injury (ALI) and alveolar-capillary …

The coronavirus disease 2019 (COVID-19) pandemic has caused considerable socio-
economic burden, which fueled the development of treatment strategies and vaccines at an …

The lung alveolar region experiences remodeling during several acute and chronic lung
diseases, as for instance idiopathic pulmonary fibrosis (IPF), a fatal disease, whose onset is …

Alterations of cell monolayer integrity and increased vascular permeability are key to many
pathologies, including atherosclerosis, stroke, lung injury, cancer, digestive disorders and …

Background Mechanistic modelling of normal tissue toxicities is unfolding as an alternative
to the phenomenological normal tissue complication probability models. The latter, currently …

Restoration of the epithelial barrier following acute lung injury is critical for recovery of lung
homeostasis. After injury, alveolar type II epithelial (ATII) cells spread and migrate to cover …

Radiation-induced lung injury (RILI) is a prevalent complication associated with
radiotherapy for thoracic tumors. Based on the pathological progression, it can be …

The aryl hydrocarbon receptor (AHR) is a receptor/transcription factor widely expressed in
the lung. The physiological roles of AHR expressed in the alveolar epithelium remain …

Wounds can be produced when cells and tissues are subjected to excessive forces, for
instance, under pathological conditions or nonphysiological loading. However, the cellular …

Acute respiratory distress syndrome (ARDS) is a disease with a variety of causes and is
defined by severe hypoxemia. Whereas ARDS carries a mortality of approximately 30 …