Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

In recent years, major advances have been made in the understanding of the cellular and
molecular mechanisms driving pulmonary vascular remodelling in various forms of …

Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last
decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin …

Abstract Sirtuin 3 (SIRT3) is a potential therapeutic target for cardiovascular, metabolic, and
other aging-related diseases. In this study, we investigated the role of SIRT3 in diabetic …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …

Sepsis is one common cause of acute lung injury (ALI) and acute respiratory distress
syndrome (ARDS), which is closely associated with high mortality in intensive care units …

Pulmonary hypertension (PH) is a serious disease characterized by various degrees of
pulmonary vasoconstriction and progressive fibroproliferative remodeling and inflammation …

The myofibroblast is a specialized fibroblast that expresses α-smooth muscle actin (α-SMA)
and participates in wound contraction and fibrosis. The fibroblast to myofibroblast transition …

Pulmonary hypertension (PH) is a progressive cardiovascular disorder in which local
vascular inflammation leads to increased pulmonary vascular remodeling and ultimately to …