Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

BACKGROUND: There is a need for more research on all forms of rhinosinusitis. Progress in
this area has been hampered by a lack of consensus definitions and the limited number of …

We possess an acute sense of temperature. Most of us seek shade on a hot summer day,
prefer a warm shower to a cold one, and enjoy red wines served at a temperature of 15–18° …

Ca2+ is an essential ion in all organisms, where it plays a crucial role in processes ranging
from the formation and maintenance of the skeleton to the temporal and spatial regulation of …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

The TRP (“transient receptor potential”) family of ion channels now comprises more than 30
cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the …

Abstract Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive,
nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and …

Osmotic homeostasis is one of the most aggressively defended physiological parameters in
vertebrates. However, the molecular mechanisms underlying osmotic regulation are poorly …

We have compared activation by heat of TRPV4 channels, heterogeneously expressed in
HEK293 cells, and endogenous channels in mouse aorta endothelium (MAEC). Increasing …