Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

Adsorptive-mediated transcytosis (AMT) provides a means for brain delivery of medicines
across the blood-brain barrier (BBB). The BBB is readily equipped for the AMT process: it …

Background Barrier function is essential for the maintenance of normal intestinal function.
Dysregulation of the intestinal barrier underlies a wide range of disorders. Aim Previously …

Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …

A wide variety of peptide drugs are now produced on a commercial scale as a result of
advances in the biotechnology field. Most of these therapeutic peptides are still administered …

The epithelial and endothelial barriers of the human body are major obstacles for drug
delivery to the systemic circulation and to organs with unique environment and homeostasis …

In order for therapeutic agents to exert their pharmacological effects, they have to cross the
biological membranes into the systemic circulation and reach the site of action. Drugs cross …

Drug delivery systems are essential components of drugs controlled release. In the last
decades, several drug delivery technologies have emerged including capsules, liposomes …

Despite significant improvement in modalities for treatment of cancer that led to a longer
survival period, the death rate of patients with solid tumors has not changed during the last …

Many new chemical entities are discovered with high therapeutic potential, however, many
of these compounds exhibit unfavorable pharmacokinetic properties due to poor solubility …