Modulating immunity as a therapy for bacterial infections
REW Hancock, A Nijnik, DJ Philpott - Nature Reviews Microbiology, 2012 - nature.com
Despite our efforts to halt the increase and spread of antimicrobial resistance, bacteria
continue to become less susceptible to antimicrobial drugs over time, and rates of discovery …
continue to become less susceptible to antimicrobial drugs over time, and rates of discovery …
Vaccines against tuberculosis: where are we and where do we need to go?
THM Ottenhoff, SHE Kaufmann - PLoS pathogens, 2012 - journals.plos.org
In this review we discuss recent progress in the development, testing, and clinical evaluation
of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has …
of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has …
[HTML][HTML] A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human
JT van Dissel, SA Joosten, ST Hoff, D Soonawala… - Vaccine, 2014 - Elsevier
Here, we report on a first-in-man trial where the tuberculosis (TB) vaccine Ag85B-ESAT-6
(H1) was adjuvanted with escalating doses of a novel liposome adjuvant CAF01. On their …
(H1) was adjuvanted with escalating doses of a novel liposome adjuvant CAF01. On their …
First-in-human trial of the post-exposure tuberculosis vaccine H56: IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults
AKK Luabeya, BMN Kagina, MD Tameris… - Vaccine, 2015 - Elsevier
Background H56: IC31 is a candidate tuberculosis vaccine comprising a fusion protein of
Ag85B, ESAT-6 and Rv2660c, formulated in IC31 adjuvant. This first-in-human, open label …
Ag85B, ESAT-6 and Rv2660c, formulated in IC31 adjuvant. This first-in-human, open label …
Progress in tuberculosis vaccine development and host-directed therapies—a state of the art review
SHE Kaufmann, C Lange, M Rao, KN Balaji… - The Lancet …, 2014 - thelancet.com
Tuberculosis continues to kill 1· 4 million people annually. During the past 5 years, an
alarming increase in the number of patients with multidrug-resistant tuberculosis and …
alarming increase in the number of patients with multidrug-resistant tuberculosis and …
Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed against Three Antigenic Islands and Largely Contained in a CXCR3+CCR6+ Th1 …
An understanding of the immunological footprint of Mycobacterium tuberculosis (MTB) CD4
T cell recognition is still incomplete. Here we report that human Th1 cells specific for MTB …
T cell recognition is still incomplete. Here we report that human Th1 cells specific for MTB …
Beyond the IFN-γ horizon: biomarkers for immunodiagnosis of infection with Mycobacterium tuberculosis
Latent infection with Mycobacterium tuberculosis (LTBI) is defined by the presence of M.
tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using …
tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using …
Antigen 85 complex as a powerful Mycobacterium tuberculosis immunogene: Biology, immune-pathogenicity, applications in diagnosis, and vaccine design
Mycobacterium tuberculosis (Mtb) is one of the most life-threatening mycobacterial species
which is increasing the death rate due to emerging multi-drug resistant (MDR) strains …
which is increasing the death rate due to emerging multi-drug resistant (MDR) strains …
Safety, tolerability, and immunogenicity of the novel antituberculous vaccine RUTI: randomized, placebo-controlled phase II clinical trial in patients with latent …
AS Nell, E D'lom, P Bouic, M Sabate, R Bosser, J Picas… - PloS one, 2014 - journals.plos.org
Objectives To evaluate the safety, tolerability and immunogenicity of three different doses (5,
25 and 50 µg) of the novel antituberculous vaccine RUTI compared to placebo in subjects …
25 and 50 µg) of the novel antituberculous vaccine RUTI compared to placebo in subjects …
Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants
C Olive - Expert review of vaccines, 2012 - Taylor & Francis
The innate immune system plays an essential role in the host's first line of defense against
microbial invasion, and involves the recognition of distinct pathogen-associated molecular …
microbial invasion, and involves the recognition of distinct pathogen-associated molecular …