Translational control plays a critical role in the regulation of gene expression in eukaryotes
and affects many essential cellular processes, including proliferation, apoptosis and …

The eukaryotic translation initiation factor eIF4E can specifically bind to the cap structure of
an mRNA 5'end, mainly regulating translation initiation and preferentially enhancing the …

The interaction of the eukaryotic translation initiation factor eIF4E with the initiation factor
eIF4G recruits the 40S ribosomal particle to the 5′ end of mRNAs, facilitates scanning to …

Although messenger RNA translation is tightly regulated to preserve protein synthesis and
cellular homeostasis, chronic exposure to interferon‐γ (IFN‐γ) in several cancers can lead to …

The translation initiation factor eIF4E mediates a rate-limiting process that drives selective
translation of many oncongenic proteins such as cyclin D1, survivin and VEGF, thereby …

The eukaryotic initiation factor 4E (eIF4E) is an emerging anticancer drug target for specific
anticancer therapy as a promising approach to overcome drug resistance and promote …

Tuberculosis is a serious infectious disease caused by human pathogen bacteria
Mycobacterium tuberculosis. Bacterial drug resistance is a very significant medical problem …

Effective treatment of tuberculosis is challenged by the rapid development of Mycobacterium
tuberculosis (Mtb) multidrug resistance that presumably could be overcome with novel multi …

Eukaryotic translation initiation factors (eIFs) are highly expressed in cancer cells, especially
eIF4E, the central regulatory node driving cancer cell growth and a potential target for …

Background: Cancer cells are frequently addicted to deregulated oncogenic protein
translation that usually arises as a consequence of increased signaling flux from eIF4F …