High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

Genome-wide analyses of metazoan transcriptomes have revealed an unexpected level of
mRNA diversity that is generated by alternative splicing. Recently, regulatory networks have …

Background Alternative splicing (AS) is a widespread regulatory mechanism in multicellular
organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS …

Alternative splicing (AS) is the process by which splice sites in precursor (pre)-mRNA are
differentially selected to produce multiple mRNA and protein isoforms. During the past few …

Understanding the mechanisms of evolution of brain pathways for complex behaviours is
still in its infancy. Making further advances requires a deeper understanding of brain …

Transition from maternal to embryonic transcriptional control is crucial for embryogenesis.
However, alternative splicing regulation during this process remains understudied. Using …

Animal species present relatively high levels of gene conservation, and yet they display a
great variety of cell type and tissue phenotypes. These diverse phenotypes are mainly …

Alternative splicing is regulated by RNA binding proteins (RBPs) that recognize pre-mRNA
sequence elements and activate or repress adjacent exons. Here, we used RNA …

The study of the evolutionary origin of vertebrates has been linked to the study of genome
duplications since Susumo Ohno suggested that the successful diversification of vertebrate …

Background: RBPs (RNA-binding proteins) perform indispensable functions in the post-
transcriptional regulation of gene expression. Numerous RBPs have been implicated in …