Antimicrobial peptides (AMPs) are regarded as a new generation of antibiotics. Besides
antimicrobial activity, AMPs also have antibiofilm, immune-regulatory, and other activities …

This Review illustrates the evaluation of permeability of lipid membranes from molecular
dynamics (MD) simulation primarily using water and oxygen as examples. Membrane …

In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …

Conspectus Biological membranes separate the interior of cells or cellular compartments
from their outer environments. This barrier function of membranes can be disrupted by …

The advent of multidrug resistance among pathogenic bacteria has attracted great attention
worldwide. As a response to this growing challenge, diverse studies have focused on the …

Antimicrobial peptides (AMPs) are anti-infectives that have the potential to be used as a
novel and untapped class of biotherapeutics. Modes of action of antimicrobial peptides …

Antimicrobial peptides (AMPs) are produced by several organisms as their first line of
defense. Constituted by amino acids, they may present different mechanisms of action. The …

Conspectus Ever since the first molecular mechanics computer simulations of biological
molecules became possible, there has been the dream to study all complex biological …

Membrane active peptides are known to porate lipid bilayers, but their exact
permeabilization mechanism and the structure of the nanoaggregates they form in …

Abstract PGLa and magainin 2 (MAG2) are amphiphilic α-helical membranolytic peptides
from frog skin with known synergistic antimicrobial activity. By systematically mutating …