[HTML][HTML] Matrix metalloproteinases and liver fibrosis (translational aspects)

E Roeb - Matrix Biology, 2018 - Elsevier
Liver fibrosis, a reversible wound-healing response to chronic cellular injury, reflects a
balance between liver repair and progressive substitution of the liver parenchyma by scar …

Regenerative potential of Wharton's jelly‐derived mesenchymal stem cells: A new horizon of stem cell therapy

H Abbaszadeh, F Ghorbani… - Journal of Cellular …, 2020 - Wiley Online Library
Umbilical cord Wharton's jelly‐derived mesenchymal stem cells (WJ‐MSCs) have recently
gained considerable attention in the field of regenerative medicine. Their high proliferation …

Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/β-catenin pathway

X Rong, J Liu, X Yao, T Jiang, Y Wang, F Xie - Stem cell research & …, 2019 - Springer
Abstract Background Mesenchymal stem cells (MSCs) are increasingly being applied as a
therapy for liver fibrosis. Exosomes possess similar functions to their parent cells; however …

Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1/PINK1/mitophagy axis and mitochondrial unfolded protein …

Y Zhao, HX Li, Y Luo, JG Cui, M Talukder, JL Li - Environmental Pollution, 2022 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a hazardous chemical which is used as a
plasticizer in the plastic products. Lycopene (LYC) is a carotenoid that has protective roles …

Role of mitochondria-endoplasmic reticulum coupling in lycopene preventing DEHP-induced hepatotoxicity

Y Zhao, JG Cui, H Zhang, XN Li, MZ Li, M Talukder… - Food & function, 2021 - pubs.rsc.org
Di (2-ethylhexyl) phthalate (DEHP) is a hazardous compound used as a plasticizer in plastic
products. As a natural carotenoid, lycopene (LYC) is considered an effective protective …

Strategies to improve the efficiency of mesenchymal stem cell transplantation for reversal of liver fibrosis

C Hu, L Zhao, J Duan, L Li - Journal of cellular and molecular …, 2019 - Wiley Online Library
End‐stage liver fibrosis frequently progresses to portal vein thrombosis, formation of
oesophageal varices, hepatic encephalopathy, ascites, hepatocellular carcinoma and liver …

Wharton's jelly mesenchymal stem cells: a concise review of their secretome and prospective clinical applications

H Drobiova, S Sindhu, R Ahmad, D Haddad… - Frontiers in Cell and …, 2023 - frontiersin.org
Accumulating evidence indicates that most primary Wharton's jelly mesenchymal stem cells
(WJ-MSCs) therapeutic potential is due to their paracrine activity, ie, their ability to modulate …

Transplantation of bone marrow mesenchymal stromal cells attenuates liver fibrosis in mice by regulating macrophage subtypes

XY Luo, XJ Meng, DC Cao, W Wang, K Zhou… - Stem Cell Research & …, 2019 - Springer
Background Liver fibrosis is a key phase that will progress to further injuries such as liver
cirrhosis or carcinoma. This study aimed to investigate whether transplantation of bone …

Administration of secretome derived from human mesenchymal stem cells induces hepatoprotective effects in models of idiosyncratic drug-induced liver injury caused …

YL Huang, C De Gregorio, V Silva, ÁA Elorza, P Léniz… - Cells, 2023 - mdpi.com
Drug-induced liver injury (DILI) is one of the leading causes of acute liver injury. While many
factors may contribute to the susceptibility to DILI, obese patients with hepatic steatosis are …

Comparative evaluation of anti-fibrotic effect of tissue specific mesenchymal stem cells derived extracellular vesicles for the amelioration of CCl4 induced chronic liver …

S Gupta, Pinky, Vishal, H Sharma, N Soni… - Stem Cell Reviews and …, 2022 - Springer
Abstract Mesenchymal Stem Cells (MSCs) derived Extracellular Vesicles (EVs) have
emerged as an effective candidate for amelioration of liver fibrosis. However, the effect and …