The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Leukocyte migration through activated venular walls is a fundamental immune response that
is prerequisite to the entry of effector cells such as neutrophils, monocytes, and effector T …

The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on
vascular surfaces, the first adhesive step during inflammation and immune surveillance …

Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

Phagocytosis is a remarkably complex and versatile process: it contributes to innate
immunity through the ingestion and elimination of pathogens, while also being central to …

Integrins are activatable molecules that are involved in adhesion and signalling. Of the 24
known human integrins, 3 are currently targeted therapeutically by monoclonal antibodies …

The topographic features of an implant, which mechanically regulate cell behaviors and
functions, are critical for the clinical success in tissue regeneration. How cells sense and …

Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the
extracellular matrix. In this Review, we draw on experiments performed in mammalian cells …

The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …